Registration Dossier
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EC number: 205-563-8 | CAS number: 142-82-5
Endpoint summary
Administrative data
Description of key information
Irritating to the skin.
Not irritating to the eyes.
Not irritating to the respiratory tract.
Key value for chemical safety assessment
Additional information
There are no skin or eye irritation data available on heptane. However, there are reliable data available for another category member. Thus, read-across was conducted based on a category-approach.
In a primary skin irritation study (Chevron Phillips Chemicals, 1982), Isooctane was applied to the intact skin of rabbits for 24 hours. At 72 hours post application, very slight erythema (grade 1) were observed in 3 of 6 rabbits. No other dermal effects were noted in the study. Based on persistent irritation at premature study termination (reversibility was not seen 72 hours after application), Isooctane was considered to be skin irritating.
The eye irritation potential of Isooctane was determined by instillation of 0.1 mL of the test material into the conjunctival sac of rabbits with subsequent washing (Chevron Phillips Chemicals, 1982). Conjunctival redness (grade 2) was noted in 4 of 6 rabbits at 1 hour post instillation and persisted in one rabbit to 24 hours. The redness reversed by 48 hours. No corneal opacity, iritis, conjunctival chemosis, or discharge was noted in any of the 6 rabbits.
In another primary eye irritation study of Chevron Phillips Chemicals (1982), the treated eyes of all animals remained unwashed. Conjunctival redness (grade 2) was noted in 3 of 6 rabbits at 1 hour post instillation and persisted in two rabbits to 24 hours. All redness reversed by 48 hours. No corneal opacity, iritis, conjunctival chemosis, or discharge was noted in any of the 6 rabbits.
The respiratory tract irritation potential of Normal-Heptane was investigated in mice after single exposure to 29.29 mg/mL followed by 81.9 mg/mL heptane separated by a 10 min exposure to room air only (Chevron Phillips Chemicals, 1982). This exposure regimen failed to produce respiratory irritancy in mice. measured as sensory irritation, e. g. increased respiration rate.
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
According to Annex 1 to Directive 67/548/EEC, Normal-Heptane is classified as skin irritant.
DSD: R38
CLP: Skin Irritation Category 2
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