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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics
Type of information:
other: toxicokinetic assessment
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: toxicokinetic assessment based on physicochemical data and available studies.

Data source

Reference
Reference Type:
other: toxicokinetic assessment
Title:
Unnamed
Year:
2012

Materials and methods

Objective of study:
toxicokinetics
Principles of method if other than guideline:
Assessment of the toxicokinetic behaviour of the substance to the extent that can be derived from the relevant available information, EC 1907/2006, Annex VII, 8.8.1

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzotriazole
EC Number:
202-394-1
EC Name:
Benzotriazole
Cas Number:
95-14-7
Molecular formula:
C6H5N3
IUPAC Name:
benzotriazole
Constituent 2
Reference substance name:
1H-1,2,3-Benzotriazole
IUPAC Name:
1H-1,2,3-Benzotriazole

Results and discussion

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
5-hydroxybenzotriazole 1.6%
4-hydroxybenzotriazole 0.32%

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): low bioaccumulation potential based on study results
Based on the physicochemical data and the supporting study by Hoffmann the toxicokinetic properties of Benzotriazole are assesssed.
Executive summary:

Absorption: for the dermal and oral route, an absorption of 100% are assumed,

for the inhalative route no relevant absorption is estimated and 10% are assumed.

Distribution: no information

Metabolism and Excretion: metabolism rate is rather low (supporting study) and no Phase II reactions may occur.

Renale and fecal excretion are the prominent excretion routes.