Registration Dossier
Registration Dossier
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EC number: 202-394-1 | CAS number: 95-14-7
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: toxicokinetic assessment
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: toxicokinetic assessment based on physicochemical data and available studies.
Data source
Reference
- Reference Type:
- other: toxicokinetic assessment
- Title:
- Unnamed
- Year:
- 2 012
Materials and methods
- Objective of study:
- toxicokinetics
- Principles of method if other than guideline:
- Assessment of the toxicokinetic behaviour of the substance to the extent that can be derived from the relevant available information, EC 1907/2006, Annex VII, 8.8.1
Test material
- Reference substance name:
- Benzotriazole
- EC Number:
- 202-394-1
- EC Name:
- Benzotriazole
- Cas Number:
- 95-14-7
- Molecular formula:
- C6H5N3
- IUPAC Name:
- benzotriazole
- Reference substance name:
- 1H-1,2,3-Benzotriazole
- IUPAC Name:
- 1H-1,2,3-Benzotriazole
Constituent 1
Constituent 2
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- 5-hydroxybenzotriazole 1.6%
4-hydroxybenzotriazole 0.32%
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): low bioaccumulation potential based on study results
Based on the physicochemical data and the supporting study by Hoffmann the toxicokinetic properties of Benzotriazole are assesssed. - Executive summary:
Absorption: for the dermal and oral route, an absorption of 100% are assumed,
for the inhalative route no relevant absorption is estimated and 10% are assumed.
Distribution: no information
Metabolism and Excretion: metabolism rate is rather low (supporting study) and no Phase II reactions may occur.
Renale and fecal excretion are the prominent excretion routes.
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