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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics
Type of information:
other: toxicokinetic assessment
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: toxicokinetic assessment based on physicochemical data and available studies.

Data source

Reference
Reference Type:
other: toxicokinetic assessment
Title:
Unnamed
Year:
2012

Materials and methods

Objective of study:
toxicokinetics
Principles of method if other than guideline:
Assessment of the toxicokinetic behaviour of the substance to the extent that can be derived from the relevant available information, EC 1907/2006, Annex VII, 8.8.1

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzotriazole
EC Number:
202-394-1
EC Name:
Benzotriazole
Cas Number:
95-14-7
Molecular formula:
C6H5N3
IUPAC Name:
benzotriazole
Constituent 2
Reference substance name:
1H-1,2,3-Benzotriazole
IUPAC Name:
1H-1,2,3-Benzotriazole

Results and discussion

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
5-hydroxybenzotriazole 1.6%
4-hydroxybenzotriazole 0.32%

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): low bioaccumulation potential based on study results
Based on the physicochemical data and the supporting study by Hoffmann the toxicokinetic properties of Benzotriazole are assesssed.
Executive summary:

Absorption: for the dermal and oral route, an absorption of 100% are assumed,

for the inhalative route no relevant absorption is estimated and 10% are assumed.

Distribution: no information

Metabolism and Excretion: metabolism rate is rather low (supporting study) and no Phase II reactions may occur.

Renale and fecal excretion are the prominent excretion routes.