Benzotriazole

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics

Type of information:

other: toxicokinetic assessment

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: toxicokinetic assessment based on physicochemical data and available studies.

Data source

Reference

Reference Type:

other: toxicokinetic assessment

Title:

Unnamed

Year:

2012

Materials and methods

Objective of study:

toxicokinetics

Principles of method if other than guideline:

Assessment of the toxicokinetic behaviour of the substance to the extent that can be derived from the relevant available information, EC 1907/2006, Annex VII, 8.8.1

Test material

Test material information

Constituent 1

Reference substance name:

Benzotriazole

EC Number:

202-394-1

EC Name:

Benzotriazole

Cas Number:

95-14-7

Molecular formula:

C6H5N3

IUPAC Name:

benzotriazole

Constituent 2

Reference substance name:

1H-1,2,3-Benzotriazole

IUPAC Name:

1H-1,2,3-Benzotriazole

Results and discussion

Metabolite characterisation studies

Metabolites identified:

yes

Details on metabolites:

5-hydroxybenzotriazole 1.6%
4-hydroxybenzotriazole 0.32%

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information): low bioaccumulation potential based on study results
Based on the physicochemical data and the supporting study by Hoffmann the toxicokinetic properties of Benzotriazole are assesssed.

Executive summary:

Absorption: for the dermal and oral route, an absorption of 100% are assumed,

for the inhalative route no relevant absorption is estimated and 10% are assumed.

Distribution: no information

Metabolism and Excretion: metabolism rate is rather low (supporting study) and no Phase II reactions may occur.

Renale and fecal excretion are the prominent excretion routes.