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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

The substance has an oral LD50 of 720 mg/kg bw. In an acute dermal toxicity test the limit dose of 2000 mg/kg bw did not lead to mortality, the dermal LD50 is set to 2000 mg/kg bw by default.
A valid inhalative LC50 is not available.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
500 mg/kg bw
Quality of whole database:
study is well described

Acute toxicity: via inhalation route

Endpoint conclusion
Quality of whole database:
The study shows drawbacks in its experimental design,
assessed by a companys expert: it is unclear if the adverse effects
are caused by the experimental design (increased temperature) or the substance itself

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
2 000 mg/kg bw
Quality of whole database:
The assessment by the regulatory organization mentions two studies,
both with insufficient documentation available.
A read-across from a study with the tolyltriazole sodium salt supports this conclusion

Additional information

Justification for selection of acute toxicity – oral endpoint
well performed study according to OECD and national guideline

Justification for selection of acute toxicity – inhalation endpoint
only one study available, which does not allow an endpoint conclusion

Justification for selection of acute toxicity – dermal endpoint
assessment by a regulatory organization

Justification for classification or non-classification



















 oral 300 < LD50 < 2000 mg/kg bw Acute Tox. 4; H302
 dermal LD50 > 2000 mg/kg bw not classified
 inhalative waiving, because exposure unlikely not classified