Registration Dossier
Registration Dossier
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EC number: 204-482-5 | CAS number: 121-57-3
Endpoint summary
Administrative data
Description of key information
Skin: not irritating
Eye: irritating
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin:
In a study according to OECD Guideline for the Testing of Chemicals, Draft Proposal for a New Guideline, In Vitro Skin Irritation: Reconstructed Human Epidermis (RhE) Test Method (Version 7.6, 9 September 2009) under GLP, the test substance did not show any skin irritation potential and is therefore consider as not skin irritating.
Eye:
in vivo: In a GLP-study according to OECD test guideline 405, the registered substance is severly eye irritating, but all effects reverse latest after 21 days.
in vitro: In an in vitro HET-CAM study under GLP, the test substance showed potential to be severly irritating to the eye.
Effects on eye irritation: irritating
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
Skin: not classified
Eye: Based on the available information, the registered substance is classified as an eye irritant (Category 2).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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