Registration Dossier
Registration Dossier
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EC number: 203-375-0 | CAS number: 106-22-9
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication which meets basic scientific principles
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Metabolism of Geraniol and Linalool in the Rat and effects on liver and Lung Microsomal Enzymes.
- Author:
- Chadha A, Madyastha M
- Year:
- 1 984
- Bibliographic source:
- Xenobiotica 14: 365-374
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Chadha A, Madyastha M
- Year:
- 2 008
- Bibliographic source:
- RIFM database
Materials and methods
- Objective of study:
- metabolism
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Geraniol
- EC Number:
- 203-377-1
- EC Name:
- Geraniol
- Cas Number:
- 106-24-1
- Molecular formula:
- C10H18O
- IUPAC Name:
- 3,7-dimethylocta-(E)-2,6-dien-1-ol
- Reference substance name:
- trans-3,7-Dimethyl-2,6-octadien-1-ol
- IUPAC Name:
- trans-3,7-Dimethyl-2,6-octadien-1-ol
- Details on test material:
- - Name of test material (as cited in study report): Geraniol
- Analytical purity: >99.5% pure,
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: IISc strain
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 160 - 200 g
- Housing: after dosing individually
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on exposure:
- VEHICLE
- Concentration: 1% - Duration and frequency of treatment / exposure:
- 6 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
600 mg/kg bw/d
- Control animals:
- yes, concurrent vehicle
- Details on dosing and sampling:
- PHARMACOKINETIC STUDY (Absorption, distribution, excretion)
- Tissues and body fluids sampled . liver, lung
- Time and frequency of sampling:24 h after 1, 3 or 6 doses.
Results and discussion
Any other information on results incl. tables
Results:
- Significant increase in liver cytochrome P-450 after 3 days.
- steady increase in liver geraniol hydroxylase activity (36% at 6 days).
- No change in cytochrome b5, NADPH- or NADH-cytochrome c reductases.
- No effect on any parameter using lung microsome.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
