Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-375-0 | CAS number: 106-22-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary literature available
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
- Reference Type:
- secondary source
- Title:
- Fragrance Raw Materials
- Author:
- Opdyke DLJ
- Year:
- 1 975
- Bibliographic source:
- Food Cosmet. Toxicol. 13, 757 - 758
- Reference Type:
- secondary source
- Title:
- RTECS: Update 199701, (2000/01)
- Author:
- Moreno OM
- Year:
- 2 001
- Bibliographic source:
- RTECS: Update 199701
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 006
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- acute dermal toxicity
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Citronellol
- EC Number:
- 203-375-0
- EC Name:
- Citronellol
- Cas Number:
- 106-22-9
- Molecular formula:
- C10H20O
- IUPAC Name:
- 3,7-dimethyloct-6-en-1-ol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- no data
- Doses:
- 1250, 2500, 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 650 mg/kg bw
- 95% CL:
- 1 780 - 3 520
- Mortality:
- 5000 mg/kg bw: 5/5
2500 mg/kg bw: 2/5
1250 mg/kg bw: 0/5 - Clinical signs:
- other: 5000 mg/kg bw: ataxia and pupillary dilation 2500 mg/kg bw: ataxia in 4 animals 1250 mg/kg bw: 2 animals were weak and unable to stand
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
