Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 940-223-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The registration substance Hostapon SLG is likely of low chronic toxicity based on the read-across approach:
The chronic toxicity of the registration substance Hostapon SLG was evaluated based on the read-across approach using the repeated dose toxicity data for Hostapon SG and sodium N-lauroyl sarcosinate.
-Hostapon SG was investigated for its repeated dose toxicity in rats according to the Guideline OECD 407. The study included recovery animal groups. Animals were treated at doses of 0, 62.5, 250 and 1000 mg/kg/day. No significant treatment related systemic effect was found up to the highest dose level. At dose of 1000 mg/kg/day microscopic changes in the forestach was found. The lesions consisted of acanthosis, parakeratosis, inflammation, ulceration and erosions. After recovery period of 14 days, these changes were completely reversible. Comparable effects were not seen in the animals of low and mid dose groups. NOAEL of 250 mg/kg/day was assigned for the forestomach local effects and NOAEL of 1000 mg/kg/day was assigned for the systemic effects.
-Sodim N-Lauroyl sarcosinate was given to rats by gavage daily at doses of 0, 30, 100, and 250 mg/kg bw for up to 92 days. Body weight gain decrease and effects on the stomach was found for animals of 100 and 250 mg/kg/day. The NOAEL was 250 mg/kg bw/day.The NOEL was 30 mg/kg/day and the NOAEL 250 mg/kg bw/day.
-Sodium N-lauroyl sarcosinate was investigated in rats for its chronic toxicity and reproduction toxicity in a 2 -year feeding study. The doses levels applied were 0, 0.2, 1 and 2% in the diet. Males and females were housed together so that fertility could be assessed. No effect on the fertility was found. Histopathological changes of stomach tissues were evident at dose levels of 1 and 2% in the diet. No significant systemic effect was found up to the highest dose level.
-Sodium N-lauroyl sarcosinate were applied to weanling rats by feeding at 2% in diet for 6 months. No effect on weight gain, feeding efficiency, general health, or behavior was observed, and no abnormalities of the internal organs were observed.
Likewise, the registration substance Hostapon SLG is likely of low chronic toxicity.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- Reliable and robust database:
- One 28-day toxicity study and subchronic/chronic toxicity studies on the structurally related substance. Consistent outcomes in all available studies
- Consistent outcomes when compared to the metabolism considerations
Additional information
Justification for classification or non-classification
The registration substance was assessed by read-across. No significant systemic effect of repeated dose toxicity can be reliably derived. No classification is warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.