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Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Administrative data

Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non GLP, TGD guideline, QSAR calculation, acceptable with restriction
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other:
Title:
The Estimation Programs Interface (EPI) SuiteTM v4.00
Author:
US Environmental Protection Agency's Office of Pollution Prevention and Toxics and Syracuse Research Corporation (SRC)
Year:
2008
Bibliographic source:
United States Environmental Protection Agency

Materials and methods

Principles of method if other than guideline:
The Ecosar class program has been developed primarily for the evaluation of neutral organic compounds and organic classes with excess toxicity. The QSARs in the Ecosar program are developed for chemical classes based on measured test data that have been submitted by industry or they are developed by other sources for chemicals with similar structures, e.g. phenols. Using the measured aquatic toxicity values and estimated Kow values, regression equations can be developed for a class of chemicals. Toxicity values for new chemicals may then be calculated by inserting the Kow into the regression equation and correcting the resultant value for the molecular weight of the compound.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Isobutane
EC Number:
200-857-2
EC Name:
Isobutane
Cas Number:
75-28-5
Molecular formula:
C4H10
IUPAC Name:
isobutane
Details on test material:
No data reported
Specific details on test material used for the study:
Details on properties of test surrogate or analogue material (migrated information):
No data reported

Sampling and analysis

Analytical monitoring:
not specified
Details on sampling:
No data reported

Test solutions

Vehicle:
not specified
Details on test solutions:
No data reported

Test organisms

Test organisms (species):
other: Green algea (no further information)
Details on test organisms:
No data reported

Study design

Test type:
not specified
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Post exposure observation period:
No data reported

Test conditions

Hardness:
No data reported
Test temperature:
No data reported
pH:
No data reported
Dissolved oxygen:
No data reported
Salinity:
No data reported
Nominal and measured concentrations:
No data reported
Details on test conditions:
No data reported
Reference substance (positive control):
not specified

Results and discussion

Effect concentrations
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
8.57 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
not specified
Details on results:
No data reported
Results with reference substance (positive control):
No data reported
Reported statistics and error estimates:
No data reported

Applicant's summary and conclusion

Validity criteria fulfilled:
not applicable
Conclusions:
The 96 hour EC50 for green algae is estimated to be 8.57 mg/L in fresh water.
Executive summary:

No experimental data are available for the effect of isobutane on the toxicity of algae so QSAR calculations were used to estimate the result. ECOSAR Program v1.00. in EPI Suite v4.00 has been used which is acceptable with restrictions. The 96 hour EC50 for green algae is estimated to be 8.57 mg/L in fresh water.