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EC number: 212-222-7 | CAS number: 770-35-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guidelines with acceptable restrictions (non-GLP, unknown purity of the testing substance)
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
- Reference Type:
- secondary source
- Title:
- SIDS for Propylene Glycol Phenyl Ether - CAS No: 770-35-4 (major isomer - Secondary Alcohol), 4169-04-4 (minor isomer - Primary Alcohol), 41593-38-8 (commercial mixed isomer product)
- Author:
- OECD
- Year:
- 2 006
- Bibliographic source:
- SIDS Initial Assessment Report For - SIAM 18- Paris, France, 20-23 April 2004
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1-phenoxypropan-2-ol
- EC Number:
- 212-222-7
- EC Name:
- 1-phenoxypropan-2-ol
- Cas Number:
- 770-35-4
- Molecular formula:
- C9H12O2
- IUPAC Name:
- 1-phenoxypropan-2-ol
- Reference substance name:
- 1-phenylpropan-2-ol
- EC Number:
- 211-821-0
- EC Name:
- 1-phenylpropan-2-ol
- Cas Number:
- 698-87-3
- IUPAC Name:
- 1-phenylpropan-2-ol
- Details on test material:
- - Name of test material (as cited in study report): Solvenon PP (Propylene glycol phenyl ether)
- Analytical purity: no data
- Impurities (identity and concentrations): no data
- Composition of test material, percentage of components: no data
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: rat/Wistar/Dr. K. Thomae GmbH, D-7950 Biberach, FRG
- Age at study initiation: young adult animals
- Weight at study initiation: 180 - 210 g
- Fasting period before study: withdrawal of food about 16 hours before sacrifice
- Housing: 5 animals per stainless steel wire mesh cages, type DK-III (Becker & Co., Castrop-Rauxel, FRG)
- Diet: Kliba-Labordiaet 343, Klingentalmuehle AG CH-4303 Kaiseraugst, Switzerland; ad libitum
- Water: tap water, ad libitum
- Acclimation period: at least one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 40 or 20 g in 100 ml
MAXIMUM DOSE VOLUME APPLIED: 5 ml/kg - Doses:
- 1000 and 2000 mg/kg body weight
- No. of animals per sex per dose:
- 5/sex/group
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: After dosing, signs and symptoms were monitored several times on the first day and at least daily thereafter on workdays. Animals were checked for morbidity and mortality twice per day on workdays and once per day on holidays. Body weights were noted on a weekly basis
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight and gross pathology
Young adult male and female Wistar rats (5/sex/group) were administered single gavage doses of 1000 or 2000 mg/kg Solvenon PP (propylene glycol phenyl ether, PPh) in an olive oil vehicle. Rats were observed for mortality and signs of toxicity for 14 days after administration of the test material. Rats were administered a single gavage dose of the test compound during the morning of day 1 after being fasted for 16 hours over the previous night. After dosing, signs and symptoms were monitored several times on the first day and at least daily thereafter on workdays. Animals were checked for morbidity and mortality twice per day on workdays and once per day on holidays. Rats were fasted for 16 hours prior to final euthanization with CO2 on day 14 and were subjected to gross necropsy. - Statistics:
- not performed
Results and discussion
- Preliminary study:
- not applicable
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- One male rat from the high dose group (2000 mg/kg group) died on day 1; all remaining rats survived the 14-day observation period.
- Clinical signs:
- other: Rats from both dose groups exhibited dyspnea, apathy, and poor general state. In the high dose group, additional symptoms included apathy, abnormal stance, staggering, atonia, paresis, absence of pain reflex, absence of corneal reflex, piloerection, and d
- Gross pathology:
- No grossly observable lesions were reported in the remaining subjects that survived until study termination.
- Other findings:
- not applicable
Any other information on results incl. tables
Table 1: Results
Group | PPh dose (mg/kg) | PPh/Olive oil ratio (mg/ml) | Volume | No. exposed | No. dead (male) | No. dead (female) | Total dead |
1 | 1000 | 200 mg/ml | 5 ml | 5 | 0/5 | 0/5 | 0/10 |
2 | 2000 | 100 mg/ml | 5 ml | 5 | 1/5 | 0/5 | 1/10 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 for Solvenon PP (propylene glycol phenyl ether, PPh) was greater than 2000 mg/kg in rats. Based on the results of the study, Solvenon PP was not classified according to EU classification
- Executive summary:
In this study, young adult male and female Wistar rats (5/sex/group) were administered single gavage doses of 1000 or 2000 mg/kg Solvenon PP (propylene glycol phenyl ether, PPh) in an olive oil vehicle. Rats were observed for mortality and signs of toxicity for 14 days after administration of the test material. Rats were administered a single gavage dose of the test compound during the morning of day 1 after being fasted for 16 hours over the previous night. After dosing, signs and symptoms were monitored several times on the first day and at least daily thereafter on workdays. Animals were checked for morbidity and mortality twice per day on workdays and once per day on holidays. Rats were fasted for 16 hours prior to final euthanization with CO2 on day 14 and were subjected to gross necropsy.
One male rat from the high dose group (2000 mg/kg group) died on day 1; all remaining rats survived the 14-day observation period. Rats from both dose groups exhibited dyspnea, apathy, and poor general state. In the high dose group, additional symptoms included apathy, abnormal stance, staggering, atonia, paresis, absence of pain reflex, absence of corneal reflex, piloerection, and dehydration. Generally, these signs disappeared after the first day. Rats from both dose groups exhibited dyspnea, apathy, and poor general state. In the high dose group, additional symptoms included apathy, abnormal stance, staggering, atonia, paresis, absence of pain reflex, absence of corneal reflex, piloerection, and dehydration. Generally, these signs disappeared after the first day. No grossly observable lesions were reported in the remaining subjects that survived until study termination.
The oral LD50 for Solvenon PP (propylene glycol phenyl ether, PPh) was greater than 2000 mg/kg in rats. Based on the results of the study, Solvenon PP was not classified according to EU classification
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