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EC number: 212-222-7 | CAS number: 770-35-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
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- Auto flammability
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- Explosiveness
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- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
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- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
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- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
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- Endpoint summary
- Stability
- Biodegradation
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- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) and in accordance with the Principles of GLP
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1-phenoxypropan-2-ol
- EC Number:
- 212-222-7
- EC Name:
- 1-phenoxypropan-2-ol
- Cas Number:
- 770-35-4
- Molecular formula:
- C9H12O2
- IUPAC Name:
- 1-phenoxypropan-2-ol
- Details on test material:
- - Name of test material (as cited in study report): DOWANOL PPH
- Physical state: clear colourless to light yellow liquid
- Analytical purity: 94.91%
- Impurities (identity and concentrations): not specified
- Composition of test material, percentage of components: not specified
- Isomers composition: not specified
- Purity test date: not specified
- Lot/batch No.: MD270852TZ
- Expiration date of the lot/batch: 25 May 1999
- Stability under test conditions: stable
- Storage condition of test material: At room temperature in the dark
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Broekman Institute , Someren, The Netherlands
- Age at study initiation: at least 6 weeks old
- Weight at study initiation: < 3.5 kg
- Housing: individual housing
- Diet (e.g. ad libitum): Standard laboratory rabbit diet (LKK-20, p e l l e t diameter 4 mm, Hope Farms, Woerden, The Netherlands) approx. 100 g per day. In addition, hay (BMI, Helmond, the Netherlands) was provided once a week
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21°C
- Humidity (%): 50%
- Air changes (per hr): 15 air changes per hour
- Photoperiod (hrs dark / hrs light): 12 hours light/dark cycle
IN-LIFE DATES: From: 22 June, 1998 To: 3 August, 1998
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.1 ml of undiluted test material
- Duration of treatment / exposure:
- single
- Observation period (in vivo):
- The eyes of each animal were examined approximately 1, 24, 48 and 72 hours, 7 and 14 days after instillation of the test substance.
- Number of animals or in vitro replicates:
- 3 male animals
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): not specified
- Time after start of exposure: The eyes o f each animal were examined approximately 1, 24, 48 and 72 hours, 7 and 14 days after instillation of the test substance
SCORING SYSTEM: Refer to attachment
TOOL USED TO ASSESS SCORE: fluorescein
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 1
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 1
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 1
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0.7
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0.3
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0.7
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 2.3
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 3
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 2.7
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 1.3
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 1.3
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 1
- Reversibility:
- fully reversible within: 72 hours
- Irritant / corrosive response data:
- Instillation of 0.1 ml of DOWANOL PPH into one eye of each of three rabbits resulted in effects on the cornea, iris and conjunctivae. The corneal injur y consisted of opacity (maximum grade 1) and epithelial damage (maximum 75-90% of the corneal area). As a result of the corneal injury , pannus (neovascularisation o f the cornea) was apparent in one animal, 7 days after instillation . The corneal injury had resolved within 7 days in two animals and within 14 days in the third animal. Iridic irritation (grade 1) was observed and had completely resolved within 48 hours in one animal, within 72 hours in the second animal and within 7 days in the third animal.
The irritation of the conjunctivae consisted of redness, chemosis and discharge and had completely resolved within 14 days in all animals. Reduced elasticity of the eyelids was observed in two animals 72 hours after instillation.
There was no evidence of ocular corrosion and staining of peri-ocular tissues was not observed. - Other effects:
- No symptoms o f systemic toxicity were observed in the animals during the test period and no mortality occurred.
Any other information on results incl. tables
none
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the results of the study, DOWANOL PPH was classified as irritating to eyes according to EU classification
- Executive summary:
The study was carried out based on the guidelines described in: EC Commission Directive 92/69/EEC,B.5, 'Acute Toxicity - Eye irritation' and OECD No.405, 'Acute Eye Irritation/Corrosion'. Single samples of 0.1 ml of DOWANOL PPH were instilled into one eye of each of three rabbits. Observations were made 1, 24, 48 and 72 hours, 7 and 14 days after instillation. Instillation of DOWANOL PPH resulted in effects on the cornea, iris and conjunctivae. The corneal injury consisted of opacity (maximum grade 1) and epithelial damage (maximum 75-90% of the corneal area). As a result of the corneal injury, pannus (neovascularisation of the cornea) was apparent in one animal, 7 days after instillation. The corneal injury had resolved within 7 days in two animals and within 14 days in the third animal. Iridic irritation (grade 1) was observed and had completely resolved within 48 hours in one animal, within 72 hours in the second animal and within 7 days in the third animal. The irritation of the conjunctivae consisted of redness, chemosis and discharge and had completely resolved within 14 days in all animals. Reduced elasticity of the eyelids was observed in two animals 72 hours after instillation. Based on these results and according to the EC criteria for classification and labelling requirements for dangerous substances and preparations (Guidelines in Commission Directive 93/21/EEC), DOWANOL PPH should be labelled as: irritating to eyes (R 36).
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