Tris(2-ethylhexyl)-4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics in vitro / ex vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

other: SNIF file released by ECHA

Title:

Unnamed

Year:

1987

Report date:

1987

Materials and methods

Objective of study:

other: To examine the skin penetration of a 5% (w/w) formulation of the test substance after a single application

Test guideline

Qualifier:

according to guideline

Guideline:

other: Penetration through human epidermis in vitro

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Tris(2-ethylhexyl)-4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate

EC Number:

402-070-1

EC Name:

Tris(2-ethylhexyl)-4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate

Cas Number:

88122-99-0

Molecular formula:

C48H66N6O6

IUPAC Name:

2-ethylhexyl 4-({4,6-bis[(4-{[(2-ethylhexyl)oxy]carbonyl}phenyl)amino]-1,3,5-triazin-2-yl}amino)benzoate

Test material form:

solid: particulate/powder

Radiolabelling:

no

Test animals

Species:

other: Samples of human epidermis

Administration / exposure

Route of administration:

dermal

Vehicle:

other: 5% test substance in a sunscreening product formulation

Control animals:

no

Results and discussion

Metabolite characterisation studies

Metabolites identified:

not measured

Any other information on results incl. tables

Approx. 0.1% (= approx. 0.05 ug/cm^2) at the high dose (10 mg of the preparation/cm^2) and approx. 1.3% (= approx 0.065 ug/cm^2) at the low dose (1 mg of the preparation/cm^2) have penetrated the epidermis 24 hours after application.