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Toxicological information

Genetic toxicity: in vivo

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Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions

Data source

Reference
Reference Type:
other: ECHA Summary
Title:
Unnamed
Year:
1987

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
Version / remarks:
1986
GLP compliance:
yes
Type of assay:
other: micronucleus assay chromosome aberration

Test material

Constituent 1
Chemical structure
Reference substance name:
Tris(2-ethylhexyl)-4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate
EC Number:
402-070-1
EC Name:
Tris(2-ethylhexyl)-4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate
Cas Number:
88122-99-0
Molecular formula:
C48H66N6O6
IUPAC Name:
2-ethylhexyl 4-({4,6-bis[(4-{[(2-ethylhexyl)oxy]carbonyl}phenyl)amino]-1,3,5-triazin-2-yl}amino)benzoate

Test animals

Species:
other: mus, NMRI

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
Olivenöl
«ENGLISCH+
Olive oil
No. of animals per sex per dose:
Male: 525 mg/kg; No. of animals: 5; Sacrifice time: 16 hours
Male: 525 mg/kg; No. of animals: 5; Sacrifice time: 24 hours
Male: 525 mg/kg; No. of animals: 5; Sacrifice time: 48 hours
Male: 1050 mg/kg; No. of animals: 5; Sacrifice time: 16 hours
Male: 1050 mg/kg; No. of animals: 5; Sacrifice time: 24 hours
Male: 1050 mg/kg; No. of animals: 5; Sacrifice time: 48 hours
Male: 2100 mg/kg; No. of animals: 5; Sacrifice time: 16 hours
Male: 2100 mg/kg; No. of animals: 5; Sacrifice time: 24 hours
Male: 2100 mg/kg; No. of animals: 5; Sacrifice time: 48 hours
Female: 525 mg/kg; No. of animals: 5; Sacrifice times: 16 hours
Female: 525 mg/kg; No. of animals: 5; Sacrifice times: 24 hours
Female: 525 mg/kg; No. of animals: 5; Sacrifice times: 48 hours
Female: 1050 mg/kg; No. of animals: 5; Sacrifice times: 16 hours
Female: 1050 mg/kg; No. of animals: 5; Sacrifice times: 24 hours
Female: 1050 mg/kg; No. of animals: 5; Sacrifice times: 48 hours
Female: 2100 mg/kg; No. of animals: 5; Sacrifice times: 16 hours
Female: 2100 mg/kg; No. of animals: 5; Sacrifice times: 24 hours
Female: 2100 mg/kg; No. of animals: 5; Sacrifice times: 48 hours

Results and discussion

Test results
Sex:
not specified
Genotoxicity:
not specified
Toxicity:
not specified

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): negative