Registration Dossier
Registration Dossier
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EC number: 402-070-1 | CAS number: 88122-99-0 UVINUL T 150
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- Version / remarks:
- 1986
- GLP compliance:
- yes
- Type of assay:
- other: micronucleus assay chromosome aberration
Test material
- Reference substance name:
- Tris(2-ethylhexyl)-4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate
- EC Number:
- 402-070-1
- EC Name:
- Tris(2-ethylhexyl)-4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate
- Cas Number:
- 88122-99-0
- Molecular formula:
- C48H66N6O6
- IUPAC Name:
- 2-ethylhexyl 4-({4,6-bis[(4-{[(2-ethylhexyl)oxy]carbonyl}phenyl)amino]-1,3,5-triazin-2-yl}amino)benzoate
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- olive oil
- No. of animals per sex per dose:
- Male : 525 mg/kg; number of animals : 5; sacrifice time : 16 hours
Male : 525 mg/kg; number of animals : 5; sacrifice time : 24 hours
Male : 525 mg/kg; number of animals : 5; sacrifice time : 48 hours
Male : 1050 mg/kg; number of animals : 5; sacrifice time : 16 hours
Male : 1050 mg/kg; number of animals : 5; sacrifice time : 24 hours
Male : 1050 mg/kg; number of animals : 5; sacrifice time : 48 hours
Male : 2100 mg/kg; number of animals : 5; sacrifice time : 16 hours
Male : 2100 mg/kg; number of animals : 5; sacrifice time : 24 hours
Male: 2100 mg/kg; number of animals : 5; sacrifice time : 48 hours
Female : 525 mg/kg; number of animals : 5; sacrifice time : 16 hours
Female : 525 mg/kg; number of animals : 5; sacrifice time : 24 hours
Female : 525 mg/kg; number of animals : 5; sacrifice time : 48 hours
Female : 1050 mg/kg; number of animals : 5; sacrifice time : 16 hours
Female : 1050 mg/kg; number of animals : 5; sacrifice time : 24 hours
Female : 1050 mg/kg; number of animals : 5; sacrifice time : 48 hours
Female : 2100 mg/kg; number of animals : 5; sacrifice time : 16 hours
Female : 2100 mg/kg; number of animals : 5; sacrifice time : 24 hours
Female : 2100 mg/kg; number of animals : 5; sacrifice time : 48 hours
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- not specified
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: not further specified
- Additional information on results:
- Observations:
Controls, 24h: 0.16% micronuclei containing PCE
Test substance: 0.11% - 0.17% micronuclei containing PCE
no change in the ratio of PCE/NCE
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
Not classified as mutagenic
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