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Registration Dossier
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EC number: 258-207-9 | CAS number: 52829-07-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April-June 1972
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Bis(2,2,6,6-tetramethyl-4-piperidyl) sebacate
- EC Number:
- 258-207-9
- EC Name:
- Bis(2,2,6,6-tetramethyl-4-piperidyl) sebacate
- Cas Number:
- 52829-07-9
- Molecular formula:
- C28H52N2O4
- IUPAC Name:
- bis(2,2,6,6-tetramethylpiperidin-4-yl) sebacate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CFY
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Source: not indicated
- Age: not indicated
- Number: 5/sex/group
- Weight at study initiation: 97-112 g
- Controls: 5/sex (vehicle)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- - Vehicle: 0.5% CMC
- Volume administered or concentration: =<16.7 mL/kg bw
The test material was prepared as a 30% suspension. Rats dosed with the vehicle alone (16. 7ml/kg) served as controls. - Doses:
- 0, 2500, 3200, 4000 and 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of weighing: once per week
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 3 700 mg/kg bw
- Mortality:
- - Males: 0/5, 2/5, 2/5, 3/5 and 5/5 at 0, 2500, 3200, 4000 and 5000 mg/kg bw
- Females: 0/5, 0/5, 0/5, 2/5 and 4/5 at 0, 2500, 3200, 4000 and 5000 mg/kg bw
- Time of death: between 42 hours and 4 days after dosing - Clinical signs:
- other: Salivation, diarrhoea and diuresis. Animals recovered within 2 days
- Gross pathology:
- Pale patches on liver lobes of animals that died.
- Other findings:
- SEX-SPECIFIC DIFFERENCES: None
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The oral LD50 was established at 3700 mg/kg bw
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