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EC number: 258-207-9 | CAS number: 52829-07-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
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- Nanomaterial pour density
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- Nanomaterial radical formation potential
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- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From Jul. 16, 1980 to Sep. 8, 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- yes
- Remarks:
- No independent repeat test conducted.
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Reaction mass of Bis(1,2,2,6,6-pentamethyl-4-piperidyl) sebacate and Methyl 1,2,2,6,6-pentamethyl-4-piperidyl sebacate
- EC Number:
- 915-687-0
- Molecular formula:
- unspecified
- IUPAC Name:
- Reaction mass of Bis(1,2,2,6,6-pentamethyl-4-piperidyl) sebacate and Methyl 1,2,2,6,6-pentamethyl-4-piperidyl sebacate
Constituent 1
Method
- Target gene:
- Histidine (his- to his+) and tryptophan (tryp- to tryp+) genes in Salmonella typhimurium and Escherichia coli respectively.
Species / strain
- Species / strain / cell type:
- other: S. typhimurium TA 1535, TA 1537, TA 1538, TA 98, TA 100 and E. coli WP2 uvr A
- Additional strain / cell type characteristics:
- not applicable
- Metabolic activation:
- with and without
- Metabolic activation system:
- Aroclor 1254-induced rat liver S9
- Test concentrations with justification for top dose:
- Toxicity test (performed on strain TA 100): 0.0001, 0.001, 0.01, 0.1, 1, 10, 50, 100, 500, 1000, and 2000 µg/0.1 mL.
Experiment (performed on all strains): 5, 10, 50, 100, 500, 1000, and 5000 µg/0.1 mL. - Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: DMSO
- Justification for choice of solvent/vehicle: None provided.
Method for suspension of refractory substances: Ultrasonication
Controls
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- other: See Table 1
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: in agar (plate incorporation)
DURATION
- Exposure duration: 48 - 55 hours at 37 degrees C.
NUMBER OF REPLICATIONS: 3 Petri dishes/strain/group.
DETERMINATION OF CYTOTOXICITY
- Method: relative total growth - Evaluation criteria:
- When the colonies had been counted, the arithmetic mean was calculated. A test substance is generally considered to be non-mutagenic if the colony count in relation to the negative control is not doubled at any concentration.
- Statistics:
- When the colonies had been counted, the arithmetic mean was calculated. Statistical analysis was not performed.
Results and discussion
Test results
- Species / strain:
- other: S. typhimurium TA 1535, TA 1537, TA 1538, TA 98, TA 100 and E. coli WP2 uvr A
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not applicable
- Positive controls validity:
- valid
- Additional information on results:
- TEST-SPECIFIC CONFOUNDING FACTORS
- Precipitation: At the concentrations of 500, 1,000, and 5,000 µg/0.1mL, the substance precipitated in soft agar. - Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
DETAILS ON EXPERIMENTAL RESULTS:
In the experiments performed without and with microsomal activation, comparison of the number of back-mutant colonies in the controls and the cultures treated with the various concentrations of the test article revealed no marked deviations.
TA 98 | TA 100 | TA 1535 | TA 1537 | TA 1538 | WP2uvrA | |||||||
Dose (µg/0.1 ml) | -S9 | +S9 | -S9 | +S9 | -S9 | +S9 | -S9 | +S9 | -S9 | +S9 | -S9 | +S9 |
solvent control | 27 | 53 | 166 | 106 | 12 | 7 | 4 | 10 | 9 | 31 | 24 | 25 |
5 | 14 | 39 | 155 | 109 | 8 | 10 | 6 | 12 | 9 | 30 | 23 | 21 |
10 | 18 | 59 | 154 | 99 | 10 | 8 | 4 | 12 | 11 | 31 | 22 | 12 |
50 | 16 | 50 | 157 | 102 | 11 | 10 | 5 | 13 | 13 | 30 | 21 | 21 |
100 | 21 | 42 | 146 | 93 | 11 | 11 | 5 | 5 | 9 | 37 | 23 | 19 |
500 | 19 | 50 | 137 | 90 | 8 | 12 | 3 | 12 | 5 | 38 | 17 | 17 |
1000 | 15 | 55 | 171 | 101 | 10 | 9 | 2 | 13 | 10 | 27 | 16 | 17 |
5000 | 15 | 65 | 142 | 94 | 5 | 10 | 0 | 7 | 5 | 28 | 17 | 11 |
positive controls: | ||||||||||||
solvent control | 17 | 45 | 180 | 146 | 11 | 12 | 11 | 17 | 9 | 32 | 19 | 15 |
concentration A | 385 | 1163 | 712 | 1131 | >1500 | 530 | 136 | 73 | ~1100 | 374 | 318 | 617 |
concentration B | 533 | 1261 | 1187 | 1932 | >2000 | 1000 | 52 | >1500 | 280 | 430 | 764 |
For details on positive controls see table 1 above.
Applicant's summary and conclusion
- Conclusions:
- No evidence for a mutagenic effect was obtained in Salmonella strains TA 98, TA 100, TA 1535, TA 1537 and TA 1538 and E.coli strain WP2 uvr A treated with up to 5000 µg/plate in experiments with and without microsomal activa¬tion.
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