Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Additional information

Acute toxicity, oral:

According to regulation (EC) 1907/2006 Annex VII column 2 the study does not need to be conducted since the substance is classified as corrosive to the skin. However, there are three citations on acute oral toxicity available (Druckrey, 1966, Bury, 1989 and Kennedy, 1991). The LC50 were between 440 (Druckrey and Kennedy) and 205 mg/kg bw (Bury). Nevertheless, two studies (Kennedy and Bury) are considered to be secondary information, the study performed by Druckrey is regarded as reliable 3.

Acute toxicity, dermal:

According to the data requirements as outlined in Annexes VII-VIII, 8.5 of Regulation (EC) 1907/2006 conduct of an acute dermal toxicity study is unjustified as inhalation of the substance is considered as major route of exposure skin contact is unlikely during production and use due to the fact that the substance in an transported isolated intermediate in accordance with regulation (EC) 1907/2006 article 18 (4) a-f.

Acute toxicity, inhalation:

According to the EU RAR 2002 one study was conducted by Batsura in 1980. Rats were exposed 4 h to DMS. The LC50 value is calculated at 45 mg/m3. "Groups of animals were sacrificed immediately following exposure and at intervals thereafter. The rats were dyspnoeic with cyanosis of the mucosae, hyperemia of the lung, and hemorrhage in the internal organs. Some animals had nasal discharge. Histological and electron microscopic

examination of lung tissue revealed hemorrhage and coagulated proteins in the alveoli. After a latent period of 5-6 hr, accumulation of edematous fluid in the air spaces developed progressively over 24-48 hr."

However, the citations is only available in Russian and very limited information are included (only RL 3 study).

Justification for classification or non-classification

Using values for acute toxicity via the oral and inhalation route which are published and found during the literature search and not based on secondary information, the harmonised classifcation according to 67/548/EEC annex 1 (index no.: 016-023-00-4) could be regarded as justified.

LD50 (oral): 440 mg/kg bw.

LC50 (inhalation): 0.045 mg/L

Classification according to regulation (EC) 1272/2008 "acute tox. 3" H301 (toxic if swallowed) and "acute tox.1" H330 (fatal if inhaled).