Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

A Buehler dermal sensitization test of Composite NaF (95.6% sodium fluoride) in guinea pigs, reported by Osmose Wood

Preserving Inc., Buffalo, NY, USA (Product Safety Labs, 1995), determined that this test substance was not sensitizing to the skin.

Migrated from Short description of key information:
Flouride salts, such as sodium fluoride, are not considered contact senitizers based on negative results of a Buehler dermal sensitization test in guinea pigs.

Justification for classification or non-classification

Classification is not required because sodium fluoride was not a skin sensitizer in guinea pigs when evaulated by the Buehler method.