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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Description of key information

The 48-Hour EC50 of the test substance to Daphnia magna in freshwater was found to be 80 mg/L, with 95% confidence limits of 67 -100 mg/L. The No Observed Effect Concentration (NOEC) was 18 mg/L.
The 48 -h EC50 of the test substance to the marine copepod, Acartia tonsa, was determined to be 418.34 mg/L, with 95% confidence limits of 279-3777 mg/L. The 48-h NOEC was determined to be 200 mg/L.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
80 mg/L
EC50/LC50 for marine water invertebrates:
418.34 mg/L

Additional information

A static, 48-h acute study, following GLP and ISO TC147/SC5/WG2 Guidelines was conducted with the marine copepod Acartia tonsa. The organisms used were 19 -25 days old, from an in-house culture. The salinity of the synthetic media was 25 -27 ppt. Concentrations used were Control, 25, 50, 100, 200, 400 mg/L, and 4 replicates of 5 animals each were exposed per concentration. Test temperature was 20 -21 °C. The 48 hr. EC50 of Poly[oxy(methyl-1,2-ethanediyl)], alpha-(2-aminomethylethyl)-omega-(2-aminomethylethoxy)- to the marine copepod, Acartia tonsa, was determined to be 418.34 mg/L, with 95% confidence limits of 279-3777 mg/L. The 48 -h NOEC was determined to be 200 mg/L.

Another 48 h static acute study was conducted with the freshwater crustacean, Daphnia magna. This test followed GLP and OECD Guideline 202. Neonates from an in-house culture were used, and were <24 hr old at test initiation. Two replicates of 10 organisms each were exposed to Control and 5 concentrations up to and including 100 mg/L. The 48-Hour EC50 of Poly[oxy(methyl-1,2-ethanediyl)], alpha-(2-aminomethylethyl)-omega-(2-aminomethylethoxy)- to Daphnia magna was found to be 80 mg/L, with 95% confidence limits of 67 - 100 mg/L. The No Observed Effect Concentration (NOEC) was 18 mg/L.