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Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Description of key information

The 72 hr EC50 of Poly[oxy(methyl-1,2-ethanediyl)], alpha-(2-aminomethylethyl)-omega-(2-aminomethylethoxy)- to the freshwater algae Pseudokirchneriella subcapitata based on growth rate was found to be 15 mg/L. The 72 hr EC50 based on yield was found to be 2.1 mg/L.  The 72 hr ErC10 was determined to be 1.4 mg/L.
The 72 hr IC50 of Poly[oxy(methyl-1,2-ethanediyl)], alpha-(2-aminomethylethyl)-omega-(2-aminomethylethoxy)- to the marine algae Skeletonema costatum was determined to be 141.72, with 95% confidence limits of 89.89-173.04 mg/L. The 72 hr ErC10 was determined to be 33.34 mg/L.

Key value for chemical safety assessment

EC50 for freshwater algae:
15 mg/L
EC50 for marine water algae:
141.72 mg/L
EC10 or NOEC for freshwater algae:
1.4 mg/L
EC10 or NOEC for marine water algae:
33.34 mg/L

Additional information

A 72-h GLP and Guideline ISO 10253 study was conducted with the marine algae Skeletonema costatum. The test temperature was 20 deg C at 30 +/- 5 ppt salinity. Standard media plus silica was used. Test concentrations were 25, 50, 100, 200 and 400 mg/L plus a Control, 6 replicates each. The culture was 3 -4 days old, in exponential growth. The 72 -h IC50 of Poly[oxy(methyl-1,2-ethanediyl)], alpha-(2-aminomethylethyl)-omega-(2-aminomethylethoxy)- to the alga Skeletonema costatum was determined to be 141.72, with 95% confidence limits of 89.89-173.04 mg/L. The 72 -h ErC10 was determined to be 33.34 mg/L.

A second 72 h study was conducted with the freshwater algae Pseudokirchneriella subcapitata, strain CCAP 278/4. This study also followed GLP and OECD Guideline 201. The test culture was one week old. Test concentrations were Control, 0.10, 0.32, 1.0, 3.2 and 10 mg/L. Three replicates of each concentration were exposed, with 6 replicates for the Control. The 72 hr EC50 of Poly[oxy(methyl-1,2-ethanediyl)], alpha-(2-aminomethylethyl)-omega-(2-aminomethylethoxy)- to Pseudokirchneriella subcapitata based on growth rate was found to be 15 mg/L by extrapolation from the growth rate inhibition curve. The 72 -h EC50 based on yield was found to be 2.1 mg/L. The 72 hr ErC10 was determined to be 1.4 mg/L.