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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted scientific standards, well documented and acceptable for assessment.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1974
Report date:
1974

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Method: Draize Test
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
m-tolylidene diisocyanate
EC Number:
247-722-4
EC Name:
m-tolylidene diisocyanate
Cas Number:
26471-62-5
Molecular formula:
C9 H6 N2 O2
IUPAC Name:
m-tolylidene diisocyanate
Details on test material:
Data on physical and chemical properties, eco-toxicity and toxicity can be used for read-across from 2,4-TDI to 2,6-TDI and mixed
TDI isomers (i.e. 80/20, 65/35, 2,4/2,6 ratios). 2,4 TDI is the major component of the TDI mixed isomers and so has the major influence
on their properties and effects. The reactivity of the 2,6-TDI isomer is somewhat less than that of 2,4-TDI but is of the same order of
magnitude. It may therefore be concluded that the effects of 2,6-TDI will be similar to those of 2,4-TDI. This is in fact observed where
there are overlapping data.

Test animals / tissue source

Species:
rabbit

Test system

Controls:
yes, concurrent no treatment
Amount / concentration applied:
undiluted
Amount applied: 0.1 ml
Observation period (in vivo):
14 days
Number of animals or in vitro replicates:
6
Details on study design:
Comment: not rinsed

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 1, 24, 72h, 7d, 14d
Score:
36.5
Max. score:
110
Reversibility:
fully reversible within: 14d
Remarks on result:
other: Maximum score at 24h, see table in free text for details

Any other information on results incl. tables

animal #

Total score (cornea + iris + conjunctiva)

.

1 min

1 hr

24 hrs

72 hrs

7 days

14 days

1

0

18

18

10

8

0

2

2

18

41

18

8

6

3

2

18

41

61

66

61

4

2

12

33

17

8

6

5

2

18

43

36

10

0

6

2

16

43

41

41

20

Averages

2

16.7

36.5

30.5

23.5

15.4

Irritation Index = 36.5/110.0

Highlly irritating. All effects resolved by day 14.

Applicant's summary and conclusion

Interpretation of results:
highly irritating
Remarks:
Migrated information
Conclusions:
Classification: irritating

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