2-methylcyclohexyl acetate

Bioaccumulation: aquatic / sediment

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

bioaccumulation in aquatic species: invertebrate

Data waiving:

other justification

Justification for data waiving:

the study does not need to be conducted because the substance has a low potential for bioaccumulation based on log Kow <=3

Justification for type of information:

JUSTIFICATION FOR DATA WAIVING
In accordance with Column 2 of REACH Annex IX, the study does not need to be conducted since the substance has a low potential for bioaccumulation (log Pow < 3).

Reference 2

Endpoint:

bioaccumulation in aquatic species: invertebrate

Type of information:

(Q)SAR

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Principles of method if other than guideline:

Calculation by EPI-Suite, EPA (USA) / BCFBAF v3.01

GLP compliance:

no

Type:

BCF

Value:

48.55 L/kg

Basis:

other: estimated by BCFBAF v3.01 (EPI Suite)

Remarks on result:

other: Log BCF from regression-based method = 1.686

The estimated bioaccumulation factor was 48.55 L/kg wet-wt (BCFWIN v3.01). The Log BCF from regression-based method was 1.686. The log Pow used is 3.06 (expkow database).

Validity criteria fulfilled:

not applicable

Conclusions:

The estimated bioaccumulation factor for 2-methylcyclohexyl acetate was 48.55 L/kg wet-wt (BCFWIN v3.01).

Executive summary:

The bioaccumulation factor was estimated by the calculation method EPI Suite / BCFWIN v3.01. The BCF for 2 -methylcyclohexyl acetate was calculated to be 48.55 L/kg wet-wt (BCFWIN v3.01). The Log BCF from regression-based method was 1.686.

Description of key information

Data waiving (Study scientifically not necessary): In accordance with Column 2 of REACH Annex IX, the study does not need to be conducted since the substance has a low potential for bioaccumulation (log Pow < 3).

Additional information

Data waiving (Study scientifically not necessary): In accordance with Column 2 of REACH Annex IX, the study does not need to be conducted since the substance has a low potential for bioaccumulation (log Pow <3).

Supporting study: The estimated bioaccumulation factor for 2-methylcyclohexyl acetate was 48.55 L/kg wet-wt (BCFWIN v3.01).