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Bioaccumulation: aquatic / sediment

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Endpoint:
bioaccumulation in aquatic species: invertebrate
Data waiving:
other justification
Justification for data waiving:
the study does not need to be conducted because the substance has a low potential for bioaccumulation based on log Kow <=3
Justification for type of information:
JUSTIFICATION FOR DATA WAIVING
In accordance with Column 2 of REACH Annex IX, the study does not need to be conducted since the substance has a low potential for bioaccumulation (log Pow < 3).
Endpoint:
bioaccumulation in aquatic species: invertebrate
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Principles of method if other than guideline:
Calculation by EPI-Suite, EPA (USA) / BCFBAF v3.01
GLP compliance:
no
Type:
BCF
Value:
48.55 L/kg
Basis:
other: estimated by BCFBAF v3.01 (EPI Suite)
Remarks on result:
other: Log BCF from regression-based method = 1.686

The estimated bioaccumulation factor was 48.55 L/kg wet-wt (BCFWIN v3.01). The Log BCF from regression-based method was 1.686. The log Pow used is 3.06 (expkow database).

Validity criteria fulfilled:
not applicable
Conclusions:
The estimated bioaccumulation factor for 2-methylcyclohexyl acetate was 48.55 L/kg wet-wt (BCFWIN v3.01).
Executive summary:

The bioaccumulation factor was estimated by the calculation method EPI Suite / BCFWIN v3.01. The BCF for 2 -methylcyclohexyl acetate was calculated to be 48.55 L/kg wet-wt (BCFWIN v3.01). The Log BCF from regression-based method was 1.686.

Description of key information

Data waiving (Study scientifically not necessary): In accordance with Column 2 of REACH Annex IX, the study does not need to be conducted since the substance has a low potential for bioaccumulation (log Pow < 3).

Key value for chemical safety assessment

Additional information

Data waiving (Study scientifically not necessary): In accordance with Column 2 of REACH Annex IX, the study does not need to be conducted since the substance has a low potential for bioaccumulation (log Pow <3).

Supporting study: The estimated bioaccumulation factor for 2-methylcyclohexyl acetate was 48.55 L/kg wet-wt (BCFWIN v3.01).