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EC number: 200-882-9 | CAS number: 75-59-2
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Two reliable acute studies are available for TMAOH.
In the key study, the nominal 48h-EC50 value to Daphnia magna was 3.0 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 3 mg/L
Additional information
Two reliable acute studies are available for TMAOH:
An acute toxicity test with Daphnia magna was carried out according to OECD 202 and GLP under static conditions. The nominal 48h-EC50 value to Daphnia magna was 3.0 mg/L (95% CI 2.7 - 3.3 mg/L). The recovery rates based on DOC measurements of samples taken at the start and the end of the test were > 80%, and therefore it is deemed acceptable to express results as nominal values . (Noack, 2001)
An acute toxicity test with Daphnia magna was carried out according to OECD 202 under static conditions. The nominal 48h-EC50 value to Daphnia magna was 13.9 mg/L (95% CI 12.2 - 15.8 mg/L). The nominal concentrations were not confirmed by analytical measurements. However, due to the high water solubility and the fact that analytical measurements in the algae test by the TMAOH Consortium (2005) indicate that the substance is stable in water, it is deemed acceptable to express results as nominal values (Sachem, Inc., 1999).
In none of the acute Daphnia studies with TMAOH, nominal concentrations were confirmed by specific analyses. In the test by Noack (2001) a recovery of >80% was determined with DOC analyses of samples taken from 4 concentrations at the beginning (0h) and at the end (48h) of the test. Furthermore, in the algae study by the TMAH Consortium (2005) in which specific analytical measurements were carried out, measured concentrations at the beginning (0 h) and the end (72 h) of the test were ranged within 91.4-96.3% and 93.8-101% of the nominal concentrations, respectively. This indicates that the test substance was also stable in the other aquatic toxicity tests.
Since the study by Noack (2001) revealed the lowest LC50 value of 3 mg/L, this study was selected as a key study.
In the 11d-chronic toxicity study of TMAC with Daphnia Magna (Dow Chemical Co.,1991), a 48h-LC50 value of 1.86 mg/L was determined, which is in the same range as the key study from Noack (2001).
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