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EC number: 200-882-9 | CAS number: 75-59-2
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
There are two studies available. In the key study, the nominal 72h-ErC50 value and NOECr value to Pseudokirchnerella subcapitata were 96.3 and 6.25 mg/L, respectively.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 96.3 mg/L
- EC10 or NOEC for freshwater algae:
- 6.25 mg/L
Additional information
A toxicity test with Pseudokirchnerella subcapitata was carried out by the TMAH Consortium (2005) according to OECD 201 and GLP under static conditions. Analytical monitoring was conducted. The TMAH concentrations in test solutions were maintained within ± 20% of nominal concentrations throughout the test. Thus the value was estimated with nominal concentrations. The nominal 72h-ErC50 value and NOECr value were 96.3 and 6.25 mg/L, respectively.
A toxicity test with Desmodesmus subspicatus was carried out by Scheerbaum (2001) in accordance with OECD 201, EU Method C.3 (Algal Inhibition test) and GLP. The nominal 72h-ErC50 value and NOECr value to Desmodesmussubspicatus were >251 and 31.4 mg/L, respectively.The recovery rates of samples taken at the start and the end of the test based on DOC measurements were > 80% and therefore it is deemed acceptable to express the results as nominal values. As no significant effects was observed in neutralised solution of 251 mg/L TMAOH (pH control), it can be concluded that the effects are pH dependent.
The study from TMAH Consortium (2005) was selected as a key study because the EC50 and NOEC values were lower. Probably Pseudokirchnerella subcapitata is more sensitive to TMAOH than Desmodesmus subspicatus. Furthermore, the nominal concentrations in the study from the TMAH Consortium (2005) were confirmed by specific analytical measurements, whereas in the study by Scheerbaum (2001) DOC measurements were carried out, which was a reason to assign a lower reliability to it.
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