Isobutyraldehyde

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Qualifier:

according to guideline

Guideline:

EU Method C.2 (Acute Toxicity for Daphnia)

GLP compliance:

no

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

Daphnia magna

Details on test organisms:

- Age of test organisms: 2-24 h
- Source: Institut National de Recherche Chimique Appliquee, France

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

48 h

Hardness:

total hardness 2.98 mmol/L

Test temperature:

292-294 K

pH:

7.54 - 8.05

Dissolved oxygen:

7.77 - 8.93 mg/L

Nominal and measured concentrations:

Nominal concentrations: 0, 31.25, 62.5, 125, 250 and 500 mg/L

Details on test conditions:

- Test was performed in non-sealed beakers
- Test volume: 10 mL
- No. test organisms: 5
- No. of replicates: 4

Key result

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

277 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other: 236.81-324.92 mg/L

Details on results:

OTHER REPORTED EFFECT CONCENTRATIONS:
48-h EC100: 500 mg/L
48-h EC0: 125 mg/L
24-h EC100: 500 mg/L
24-h EC50: 308 mg/L
24-h EC0: 125 mg/L

Description of key information

The 48-h EC50 value is 277 mg/L in aquatic invertebrates (D. magna).

Additional information

The acute toxicity to aquatic invertebrates was determined in a study according to Directive 79/831/EEC, Annex V, Part C. In this study daphnids (D. magna, 20 per concentration) were exposed to nominal concentrations of 0, 31.25, 62.5, 125, 250 and 500 mg/L for 48 hours under static conditions. Immobilization was recorded after 24 and 48 hours exposure. At a test concentration of 125 and 500 mg/L cumulative mortality was 0% and 100%, respectively. Based on these findings the 48-h EC50 value was determined at 277 mg/L.