Registration Dossier
Registration Dossier
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EC number: 201-149-6 | CAS number: 78-84-2
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Catalysis by cytochrome P-450 of an oxidative reaction in xenobiotic aldehyde metabolism: deformylation with olefin formation
- Author:
- Roberts E.S.
- Year:
- 1 991
- Bibliographic source:
- Proc Natl Acad Sci U S A;88(20):8963-6.
Materials and methods
- Objective of study:
- metabolism
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Isobutyraldehyde
- EC Number:
- 201-149-6
- EC Name:
- Isobutyraldehyde
- Cas Number:
- 78-84-2
- Molecular formula:
- C4H8O
- IUPAC Name:
- 2-methylpropanal
- Details on test material:
- - Name of test material: Isobutyraldehyde
Constituent 1
- Radiolabelling:
- no
Administration / exposure
- Details on study design:
- The individual P-450 cytochromes were purified from either rabbit nasal microsomes or liver microsomes. Isobutyraldehyde was incubated with the P-450 enzymed for 20 minutes at 37°C. All hydrocarbon products were analyzed by GC by comparison to authentic standards.
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Isobutyraldehyde was converted to propylene by cytochrome P-450
Applicant's summary and conclusion
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