Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-149-6 | CAS number: 78-84-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-finding toxicity data
- Author:
- Smyth H.F.
- Year:
- 1 954
- Bibliographic source:
- AMA Arch Ind Hyg Occup Med. 1954 Jul;10(1):61-8.
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
- Reference Type:
- publication
- Title:
- Industrial hygiene and toxicology, Second Revised Edition, Volume II
- Author:
- Fassett D.W.
- Year:
- 1 962
- Bibliographic source:
- p. 1966-1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Five female Carworth Wistar per dose were exposed to the test substance. Based upon mortalities during a 14-day observation period, the most probable LD50 value and its fiducial range are estimated by the method of Thompson using the tables of Weil.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Isobutyraldehyde
- EC Number:
- 201-149-6
- EC Name:
- Isobutyraldehyde
- Cas Number:
- 78-84-2
- Molecular formula:
- C4H8O
- IUPAC Name:
- 2-methylpropanal
- Details on test material:
- - Name of test material: isobutyraldehyde
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Carworth Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Mellon Institute of Industrial Research, University of Pittsburg
- Age at study initiation: 5-6 weeks
- Weight at study initiation: 90 – 120 g
- Fasting period before study: not performed
- Diet: Rockland rat diet
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 1% solution of sodium 3,9-diethyl-6-tridecanol sulfate (Tergitol Penetrant 7)
- Details on oral exposure:
- Administered as a 20% aqueous dispersion in 1% Tergitol Penetrant 7
- Doses:
- 2000, 3980, 7950 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- Duration of observation period following administration: 14 days
- Statistics:
- LD50 and its fiducial range are estimated by the method of Thompson using the tables of Weil.
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 3 730 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 2 680 - 5 210
- Gross pathology:
- Severe gastrointestinal tract necrosis was observed. The liver, spleen and kidneys were also necrosed where they contacted the stomach wall. Lungs wer markedly congested or hemorrhagic.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
