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EC number: 930-397-4
CAS number: 1174918-63-8
Perbellini et al. (1981) measured
metabolites in shoe workers exposed to n-hexane. Mean concentrations of
n-hexane metabolites in urine were: 2,5-hexanedione, 5.4 mg/L;
2,5-dimethylfuran, 3.7 mg/L; gamma-valerolactone, 3.3 mg/L; and
2-hexanol, 0.19 mg/L. (2,5-Dimethylfuran and gammavalerolactone were
believed to be artifacts of sample preparation and analysis rather than
true metabolites of nhexane) (ATSDR 1999). The first reaction that takes
place is hydroxylation of n-hexane at the 2 position to form 2-hexanol.
Further reactions result in 2,5-hexanedione, presumably through
transient intermediates, including 2-hexanone, 2,5-hexanediol, and
5-hydroxy-2-hexanone. Correlations between concentrations of n-hexane in
air and urinary metabolites were best for total n-hexane metabolites
(r=0.7858), followed by 2 -hexanol (r=0.6851) and 2,5 -hexanedione
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