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Toxicological information

Dermal absorption

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Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
2000
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This study is classified as reliable with restrictions because it is an acceptable, well-documented study report that followed basic scientific principles.

Data source

Reference
Reference Type:
publication
Title:
Skin absorption of some vaporous solvents in volunteers.
Author:
Kezic S, Monster AC, Krüse J, Verberk MM.
Year:
2000
Bibliographic source:
Int Arch Occup Environ Health. 2000 Aug;73(6):415-22.

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Five volunteers were dermally exposed on an area of about 1,000 cm2 (forearm and hand) for 20 or 30 min to hexane vapour.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Hydrocarbons, C5-C7, n-alkanes, isoalkanes, n-hexane rich
EC Number:
930-397-4
Cas Number:
1174918-63-8
Molecular formula:
Combination of CnH2n+2 structures and comprised mainly within a carbon number range from C5 to C7.
IUPAC Name:
Hydrocarbons, C5-C7, n-alkanes, isoalkanes, n-hexane rich
Details on test material:
hexane

Test animals

Species:
human
Strain:
not specified

Administration / exposure

Details on study design:
The dermal absorption rate for hexane (HEX) in humans was determined. Five volunteers were dermally exposed on an area of about 1,000 cm2 (forearm and hand) for 20 or 30 min. An inhalation exposure with a known dose rate served as a reference. Using the solvent concentrations in exhaled air, measured after both inhalation and dermal exposure, we calculated the maximum absorption rate into the blood, and the average absorption rates into the skin throughout the exposure, using the linear system dynamics method.

Results and discussion

Signs and symptoms of toxicity:
not specified
Dermal irritation:
not examined
Absorption in different matrices:
The absorption rates into the skin, normalised for exposure concentration, was determined to be 0.013 cm/h (HEX). The maximum absorption rate into the blood was determined to be 0.005 nmol/h. A comparison of the estimated whole-body skin uptake with the inhalatory uptake from the same atmosphere, revealed that the dermal uptake contributed 0.1% (HEX) to the total uptake.

Applicant's summary and conclusion

Conclusions:
The absorption rates into the skin, normalised for exposure concentration, was determined to be 0.013 cm/h (HEX). The maximum absorption rate into the blood was determined to be 0.005 nmol/h. A comparison of the estimated whole-body skin uptake with the inhalatory uptake from the same atmosphere, revealed that the dermal uptake contributed 0.1% (HEX) to the total uptake.
Executive summary:

The absorption rates into the skin, normalised for exposure concentration, was determined to be 0.013 cm/h (HEX). The maximum absorption rate into the blood was determined to be 0.005 nmol/h. A comparison of the estimated whole-body skin uptake with the inhalatory uptake from the same atmosphere, revealed that the dermal uptake contributed 0.1% (HEX) to the total uptake.