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EC number: 930-397-4
CAS number: 1174918-63-8
skin sensitisation study was conducted to determine the concentration of
“hexane” that would be expected to cause sensitization in humans
(Basketter, 2000, Klimisch=2).
of previous LLNA experiments were used to calculate the EC3 value, the
concentration at which the test substance would produce a 3 -fold
increase in the proliferative activity of lymph nodes in the LLNA test.
The 3 -fold increase is considered a positive response for sensitization
in the LLNA test. The EC3 value for hexane was determined to be > 100%
concentration. The test substance is therefore not sensitising. Therefore,
hexane solvent containing between 5 and 80% n-hexane are not expected to
on data for n-hexane, there are no reports of respiratory sensitization
laboratory animals or humans. A skin sensitization study utilizing n-
hexane found no indication of skin sensitization in guinea pigs. With
this observation, it is presumed that commercial hexane solvent
containing between 5 and 80% n-hexane will not be a respiratory
The test substance
is not classified for the sensitsation endpoint.
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