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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to soil macroorganisms except arthropods

Currently viewing:

Administrative data

Endpoint:
toxicity to soil macroorganisms except arthropods: short-term
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
results derived from a (Q)SAR model, with limited documentation / justification
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: Software
Title:
No information
Author:
ECOSAR™
Year:
2009
Bibliographic source:
v1.00, included in the US EPA Suite 4.0

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD Series on Testing and Assessment No. 69 (Validation of QSAR)
Deviations:
yes
Remarks:
- The validity criterion 4 “Suitable statistical evaluation” is not met. The training set of eight components only is not suitable.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2,3-trichloropropane
EC Number:
202-486-1
EC Name:
1,2,3-trichloropropane
Cas Number:
96-18-4
Molecular formula:
C3H5Cl3
IUPAC Name:
1,2,3-trichloropropane

Test organisms

Test organisms (species):
other: Earthworm in general
Animal group:
annelids

Study design

Study type:
other: Base line Toxicity calculation for neutral organics
Substrate type:
not specified
Limit test:
no
Total exposure duration:
14 d
Remarks:
base for estimation

Results and discussion

Effect concentrations
Duration:
14 d
Dose descriptor:
LC50
Effect conc.:
240.322 mg/kg soil dw
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: expressed as ppm

Any other information on results incl. tables

ECOSAR v1.00 Class(es) Found

------------------------------

Neutral Organics

ECOSAR Class           

Organism

Duration

End Pt

Predicted
mg/L (ppm)

Neutral Organics

Earthworm

14-day

LC50

240.322 *

Note: * = asterisk designates: Chemical may not be soluble enough to measure this predicted effect.

Applicant's summary and conclusion

Validity criteria fulfilled:
no
Conclusions:
The calculated base line toxicity to earthworms is LC50 of 240.322 ppm or mg/kg soil.
Executive summary:

The base line toxicity was calculated. Under the provision that no other than narcotic mode of action is relevant and the prediction can be based on log Kow , water solubility and melting point only the QSAR model predicts for DCDPS an LC50 of 240.322 ppm for effects of DCDPS to earthworms.

However the QSAR is invalid with regard to the OECD criteria (Series on Testing and Assessment No. 69, Validation of QSAR).