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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

LD50 (oral) in rats: in the range of 8000 mg/kg bw (no lethality occurred at a dose of 2000 mg/kg bw)
LD50 (dermal) in rats: > 2000 mg/kg bw (no substance related mortality)
LC50 (inhalation) in the rat: no mortality at 2.08 mg/L/4 h (= the highest TAED exposure concentration tested)

Key value for chemical safety assessment

Additional information

TAED is of very low acute toxicity. The TAED oral LD50 in rats is in the range of 8 g/kg bw, no lethality occurred at a dose of 2 g/kg bw. Based on the results derived from the 90 -d dermal repeated dose study in rats (no substance related mortality at 2000 mg/kg bw), an acute dermal LD50 > 2000 mg/kg bw can be assumed. At the highest TAED exposure concentration tested

for acute inhalation toxicity (2.08 mg/L) no mortality occurred. Only minor, unspecific clinical sings were noted consiting of ocular/nasal discharge (up to 1 hour after removal) and hunched position/hypoactivity (during the first 30 min of exposure). These findings are typically observed during the inhalation of high dust concentrations and indicative of discomfort and not of substance specific effects.

Justification for classification or non-classification

Based on the available experimental data (LD50 oral >2000 mg/kg, LD50 dermal >2000 mg/kg, LC50 inhalation > 2.08 mg/L/4h) it is concluded that TAED is not subject to classification and labelling according to Directive 67/548/EEC and Regulation 1272/2008/EC for acute oral, dermal and inhalation toxicity.