Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 234-123-8 | CAS number: 10543-57-4
Endpoint summary
Administrative data
Description of key information
LD50 (oral) in rats: in the range of 8000 mg/kg bw (no lethality occurred at a dose of 2000 mg/kg bw)
LD50 (dermal) in rats: > 2000 mg/kg bw (no substance related mortality)
LC50 (inhalation) in the rat: no mortality at 2.08 mg/L/4 h (= the highest TAED exposure concentration tested)
Key value for chemical safety assessment
Additional information
TAED is of very low acute toxicity. The TAED oral LD50 in rats is in the range of 8 g/kg bw, no lethality occurred at a dose of 2 g/kg bw. Based on the results derived from the 90 -d dermal repeated dose study in rats (no substance related mortality at 2000 mg/kg bw), an acute dermal LD50 > 2000 mg/kg bw can be assumed. At the highest TAED exposure concentration tested
for acute inhalation toxicity (2.08 mg/L) no mortality occurred. Only minor, unspecific clinical sings were noted consiting of ocular/nasal discharge (up to 1 hour after removal) and hunched position/hypoactivity (during the first 30 min of exposure). These findings are typically observed during the inhalation of high dust concentrations and indicative of discomfort and not of substance specific effects.
Justification for classification or non-classification
Based on the available experimental data (LD50 oral >2000 mg/kg, LD50 dermal >2000 mg/kg, LC50 inhalation > 2.08 mg/L/4h) it is concluded that TAED is not subject to classification and labelling according to Directive 67/548/EEC and Regulation 1272/2008/EC for acute oral, dermal and inhalation toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
