Registration Dossier
Registration Dossier
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EC number: 918-139-9 | CAS number: 1228577-90-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 1,2-Diaminotoluene, propoxylated
- EC Number:
- 918-139-9
- Cas Number:
- 1228577-90-9
- Molecular formula:
- (C3H6O)n (C3H6O)n (C3H6O)n (C3H6O)n C7H10N2 sum of n: >1 - <8.5
- IUPAC Name:
- 1,2-Diaminotoluene, propoxylated
- Details on test material:
- Diaminotoluene, propoxylated, purity >99%
TERCAROL* 5903, Supplier: The Dow Chemical Company
- Molecular weight: Mn = 340 g/mole
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- 12 weeks of age. Bodyweight: 195-2019 g.
Housed in gorups fo three wiht free access to drinking water and food throughout the study.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- arachis oil
- Doses:
- 2000 mg/kg bw single dose
- No. of animals per sex per dose:
- 6 femalse in groups of three treated with 2000 mg/kg bw single dose.
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
- Mortality:
- 1 aniaml was found dead 4 hours after dosing.
- Clinical signs:
- other: Three animals in hunched posture and occasional body tremors.
- Gross pathology:
- For the animal that died the following abnormalities were noted: red lung, dark liver, dark kidneys, and epithelial sloughing of the gastric muscoa and non-glandular region of the stomach.
No abnormalities were noted at necropsy of the animals that were killed at the end of the study.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- An LD50 of > 2500 mg/kg bw was determined following the acute LD50 Class method (highest does tested 2000 mg/kg bw).
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