Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 918-139-9 | CAS number: 1228577-90-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: 1a GLP guideline study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 1,2-Diaminotoluene, propoxylated
- EC Number:
- 918-139-9
- Cas Number:
- 1228577-90-9
- Molecular formula:
- (C3H6O)n (C3H6O)n (C3H6O)n (C3H6O)n C7H10N2 sum of n: >1 - <8.5
- IUPAC Name:
- 1,2-Diaminotoluene, propoxylated
- Details on test material:
- - Name of test material (as cited in study report): O-Diaminotoluene, propoxylated
- Physical state: red, extremely viscous liquid
- Molecular weight: Mn = 340 g/mole
- Composition of test material, percentage of components: Propylene oxide (100%)
- Lot/batch No.: QC 28080735
- Storage condition of test material: room temperature in the dark, over silica gel
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ORGANISMS:
- Source: Bantin & Kingman, Hull, UK
- Age: 8 to 12 weeks
- Weight at study initiation: > 200 g
- Group size: individual housing
- Controls:
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- ADMINISTRATION:
- Area covered: approx 10% of total body surface
- Occlusion: semi occluded with self-adhesive bandage
- Vehicle: undiluted
- Concentration in vehicle: undiluted
- Total volume applied: not specified
- Doses: single dose: 2000 mg/kg bw.
- Removal of test substance: - Doses:
- single dose: 2000 mg/kg b.w.
- No. of animals per sex per dose:
- 5
- Details on study design:
- EXAMINATIONS:
During and after exposure, animals were observed for signs of toxicity 30 min, 1, 2 and 4 hours after dosing and subsequently once daily for fourteen days. AT the end of the study, all animals were killed and subject to gross necropsy (external examination, opening of the abdominal and thoracic cavities.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: (nominal)
- Mortality:
- There were no deaths during the study.
- Clinical signs:
- other: No signs of systemic toxicity.
- Gross pathology:
- No abnormalities noted at necropsy
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal median lethal does (LD50) was found to be greater than 2000 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
