Registration Dossier
Registration Dossier
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EC number: 203-686-1 | CAS number: 109-60-4
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VII
- Author:
- Smyth HF, Carpenter CP, Weil CS, Pozzani UC, Striegel JA, Nycum JS
- Year:
- 1 969
- Bibliographic source:
- Am. Ind. Hyg. Assoc. J. 30: 470-476
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 961
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A flooding volume of 0.5 ml was instilled directly into the eye of 5 rabbits; eyes were not rinsed. Eye injury was recorded in a 10-grade series
(Grade 1 negligible injury), based upon the degree of corneal injury. See: Carpenter and Smyth, 1946. Chemical Burns of the Rabbit Cornea.
American J. Ophthalmology 29: 1363. - GLP compliance:
- no
Test material
- Reference substance name:
- Propyl acetate
- EC Number:
- 203-686-1
- EC Name:
- Propyl acetate
- Cas Number:
- 109-60-4
- Molecular formula:
- C5H10O2
- IUPAC Name:
- propyl acetate
- Details on test material:
- Purity unknown
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
not reported
ENVIRONMENTAL CONDITIONS
not reported
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- unrinsed
- Observation period (in vivo):
- 18 - 24 h
- Number of animals or in vitro replicates:
- 5
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: irritation
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- > 0
- Remarks on result:
- other: Propyl acetate was designated Grade 2 on a scale of 10 (slight irritation). These results indicate that n-propyl acetate causes minimal corneal injury.
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1
- Reversibility:
- fully reversible
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- fully reversible
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- fully reversible
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- fully reversible
- Remarks on result:
- positive indication of irritation
Any other information on results incl. tables
The corneal injury in rabbits was reported in Smyth et al. 1969 as grade 2 (0.5 ml undiluted gives injury of over 1.0 up to 5.0 points). OECD SIDS reported that "instillation of an excess amount of undiluted propyl acetate into the rabbit eye produced some diffuse corneal injury, which healed quickly. Propyl acetate was designated Grade 2 on a scale of 10 (slight irritation). These results indicate that n-propyl acetate causes minimal corneal injury."
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
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