Registration Dossier

Physical & Chemical properties

Explosiveness

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Administrative data

Endpoint:
explosive properties of explosives
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: regulation EG No 1272/2008 by differential scanning calorimetry
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Valproic acid
IUPAC Name:
Valproic acid
Details on test material:
- Supplied by Parke-Davis Pharmaceutical Research Division
- The percentages of active component (valproic acid) were determined by a gas-chromatographic assay for purposes of dose calculation.

Results and discussion

Small-scale preliminary tests
Parameter:
other: decomposition energy (J/g)
Remarks on result:
other: Since the absolute value of the decomposition energy was below 500 J/g the substance can be classified as non-explosive.
Remarks:
No further testing is required.

Any other information on results incl. tables

The explosive properties of 2-Propylvaleric acid were determined according to regulation EG No 1272/2008 by differential scanning calorimetry. Samples of the test substance were filled into gold plated high pressure crucibles and heated to 500 °C in a differential scanning calorimeter. The test was performed twice. The onset temperature of the exothermal decomposition reaction was 𝑻onset = 162 °C.

with a decomposition energy of Δ𝑼 = −19 ± 1 J/g and 𝑻onset = 392 °C with a decomposition energy of Δ𝑼 = −84 ± 4 J/g. Since the absolute value of the decomposition energy was below 500 J/g the substance can be classified as non-explosive. No further testing is required.

Applicant's summary and conclusion

Interpretation of results:
other: non explosive
Conclusions:
Valproic acid is considered non explosive.