Registration Dossier

Physical & Chemical properties

Melting point / freezing point

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Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
Valproic acid and sodium valproate: comprehensive profile
Author:
Alsarra, Al-Omar and Belal
Year:
2005
Bibliographic source:
Profiles of drug substances, excipients, and related methodology, volume 32

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: no information on the method but a Thomas-Hoover capillary melting point apparatus was used
GLP compliance:
not specified
Type of method:
capillary method

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium valproate
EC Number:
213-961-8
EC Name:
Sodium valproate
Cas Number:
1069-66-5
Molecular formula:
C8H16O2.Na
IUPAC Name:
sodium 2-propylpentanoate

Results and discussion

Melting / freezing point
Key result
Decomposition:
no
Remarks on result:
not determinable
Remarks:
sodium valproate does not melt

Applicant's summary and conclusion

Conclusions:
Sodium valproate does not melt, decompose or physically change in the normal working range of the Thomas-Hoover capillary melting point apparatus.