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Physical & Chemical properties

Vapour pressure

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Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
GLP compliance:
yes (incl. QA statement)
Type of method:
dynamic method

Test material

Constituent 1
Reference substance name:
Valproic acid
IUPAC Name:
Valproic acid
Details on test material:
- Supplied by Parke-Davis Pharmaceutical Research Division
- The percentages of active component (valproic acid) were determined by a gas-chromatographic assay for purposes of dose calculation.

Results and discussion

Vapour pressureopen allclose all
Key result
Temp.:
20 °C
Vapour pressure:
0.8 Pa
Key result
Temp.:
25 °C
Vapour pressure:
1.3 Pa
Vapour pressure at 50°C (if relevant for classification of gas under pressure)
Key result
Vapour pressure:
13.7 Pa

Any other information on results incl. tables

The vapour pressure of the test item was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50°C, according to Regulation EC No. 440/2008 Method A.4. and OECD Guideline 104.

Applicant's summary and conclusion

Conclusions:
Valproic acid has a vapour pressure of 0.8, 1.3 and 13.7 Pa at 20, 25 and 50°C, respectively.