Registration Dossier
Registration Dossier
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EC number: 202-777-3 | CAS number: 99-66-1
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- no
- Type of method:
- flask method
Test material
- Reference substance name:
- Valproic acid
- IUPAC Name:
- Valproic acid
- Details on test material:
- - Supplied by Parke-Davis Pharmaceutical Research Division
- The percentages of active component (valproic acid) were determined by a gas-chromatographic assay for purposes of dose calculation.
Constituent 1
Results and discussion
Water solubility
- Key result
- Water solubility:
- 1.69 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 5 other: g
- Incubation duration:
- >= 72 - <= 76 h
- Temp.:
- 20 °C
- pH:
- 4
Applicant's summary and conclusion
- Conclusions:
- Valproic acid has a water solubility of 1.69 g/L at 20°C.
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