Registration Dossier
Registration Dossier
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EC number: 209-599-5 | CAS number: 587-26-8
Sediment toxicity
Administrative data
Link to relevant study record(s)
Description of key information
NOEC >= 2327 mg Lanthanum choride, anhydrous/kg dw, corresponding to >= 1318 mg La/kg dw (highest tested concentration)
Key value for chemical safety assessment
Additional information
No data for sediment toxicity are available for Lanthanum carbonate. Therefore data from the analogue source substance Lanthanum chloride were applied to cover the respective endpoint.
The sediment toxicity was investigated according to OECD 218 under GLP conditions (Dietzmann 2010). First instar larvae of Chironomus riparius were exposed to a concentration range in a sediment water system, in which the test item Lanthanum trichloride hexahydrate was spiked into the sediment. Nominal concentrations were 673 - 3407 mg Lanthanum trichloride hexahydrate/kg dw, according to 460 - 2327 mg Lanthanum trichloride, anhydrous/kg dw calculated from the measured La concentration of the stock solution. Chironomid emergence and development rate were measured at the end of the exposure period of 28 days. The EC50 could not be calculated because none of the concentrations tested had shown toxic effects to the chironomids. The NOEC could be stated as ≥ 2327 mg Lanthanum chloride, anhydrous/kg dw.
Since Lanthanum chloride has a high water solubility (861 g/L) compared to the water solubility of Lanthanum carbonate (1.24 mg/L), the test conditions has to be evaluated as a worst case scenario. It is to be expected, that the same study perfomed with Lanthanum carbonate will show also no effects in this concentration range, since the Lanthanum ion of this test item is considerably lower bioavailable to the sediment organisms.
Further information about the analogue source substances can be found in the data matrix of the justification for the analogue approach, which can be found either in the CSR or as attachment in Iuclid section 13.
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