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Environmental fate & pathways

Adsorption / desorption

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Endpoint:
adsorption / desorption: screening
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance has a low octanol water partition coefficient and the adsorption potential of this substance is related to this parameter
Endpoint:
adsorption / desorption: screening
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
See attached QMRF/QPRF
Principles of method if other than guideline:
The method has been developed specifically for organosilicon compounds. It is a linear regression based model. The descriptors are the log Kow and an indicator variable for the presence of an amine. See QMRF and QPRF for further details.
Sample No.:
#1
Type:
log Koc
Value:
-0.6 dimensionless
pH:
7
Temp.:
20 °C
Remarks on result:
other: Predicted for the silanol hydrolysis product 3 -aminopropylsilanetriol
Conclusions:
A predicted log Koc value of -0.6 at 20°C and pH 7 was determined for the silanol hydrolysis product of the submission substance using a relevant estimation method. The result is considered to be reliable.

Description of key information

Adsorption/desorption:

log Koc [3-(trimethoxysilyl)propylamine: not relevant due to rapid hydrolysis in contact with water

log Koc [3-aminopropylsilanetriol]: -0.6 at 20°C and pH 7 (QSAR)

Key value for chemical safety assessment

Additional information

3-(Trimethoxysilyl)propyl)amine hydrolyses rapidly (2.6 hours at pH 7) to the silanol hydrolysis product 3-aminopropylsilanetriol and methanol. Both hydrolysis products have low log Kow values (<3) and thus have low potential for adsorption and the requirement for testing is waived. In view of this hydrolysis rate, risk assessment for the registered substance is carried out for the silanol hydrolysis product, 3-aminopropylsilanetriol and methanol.

The log Koc of the silanol hydrolysis product, 3-aminopropylsilanetriol has been predicted using a validated QSAR estimation method to be -0.6 at 20°C and pH 7.