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EC number: 237-511-5 | CAS number: 13822-56-5
The key acute oral and dermal studies are the only available data for the registered substance for these endpoints (BRRC, 1980a and 1980c) and identified LD50 values of 3010 and 11460 mg/kg respectively. The studies were carried out according to protocols that were similar to appropriate OECD test guidelines, but pre-dated GLP, and were therefore assigned reliability 2. No reliable acute inhalation data are available for the registered substance. However, in the same study as the key acute oral and dermal data were reported, there were no mortalities among rats exposed to substantially saturated vapour for 6 hours.
Table 1: Number of animals dead [and with evident toxicity] [and time range within which mortality occurred]
Time range of deaths (days)
Weight change (g)
75 to 107 (mean 95)
Sluggish @ 10 mins; one death @ 15 mins.
-31 to 108 (mean 61)
Sluggish and unsteady gait @ 2 mins; salivation @ 10 mins; death of 3 @ 6 min-2.5 h.
Table 1: Number of animals dead and with evident toxicity, and time range within which mortality occurred
Mortality (# dead/total)
Local skin effects
Body weight change (g)
[as reported – initial body weight not given]
Scabbing in1 of 2 on day 14
In fatalities: discoloured liver (mottled red and tan, white spots) and kidneys (tan).
In survivors: discoloured livers (dark red) and kidneys (mottled tan and red).
Erythema, oedema, desquamation and necrosis; full details not presented.
-784 to 239 (mean 239)
1, 2, 4
Erythema, oedema, desquamation, necrosis and fissuring in the survivor; full details not presented.
* two different samples of test substance used for 2 rabbits in each case
In the key acute oral toxicity study (BRRC, 1980a), an LD50 value 2.97 ml/kg was determined for male rats in a study that was carried out according to a protocol that was similar to OECD 401 but was not compliant with GLP. Clinical signs included sluggishness and unsteady gait. Necropsy of animals that died during the study revealed purple-coloured glandular portions of the stomach. Based on a relative density of 1.014, the LD50 was approximately 3010 mg/kg bw.
In the key acute dermal toxicity study (BRRC, 1980c), an LD50 value of 11.3 ml/kg was determined for rabbits in a study that was carried out according to a protocol that was similar to OECD 402 but was not compliant with GLP. No clinical signs were reported, but severe local effects were observed at the higher dose levels of 8 and 16 ml/kg. In fatalities, necropsy findings were discoloured liver (mottled red and tan, white spots) and kidneys (tan). In survivors, discoloured livers (dark red) and kidneys (mottled tan and red). Based on a relative density of 1.014, the LD50 was approximately 11460 mg/kg bw.
Based on the available data for the oral, inhalation and dermal routes, 3-(trimethoxysilyl)propylamine does not require classification for acute toxicity according to Regulation (EC) 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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