Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 270-790-1 | CAS number: 68478-10-4 A complex combination of hydrocarbons obtained by the distillation of debenzenized light steam-cracked naphtha. It consists predominantly of cyclic olefinic and aromatic hydrocarbons having carbon numbers predominantly in the range of C8 through C16 and boiling in the range of approximately 130°C to 300°C (226°F to 572°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Some information in this page has been claimed confidential.
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22 September - 18 October 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant, guideline study, available as unpublished report, no restictions, fully adequate for assessment.
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- Doses of DCPD 75%: 500, 794, 1260 & 2000 mg/kg/bw
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Details on test material:
- - Name of test material (as cited in study report): DCPD 75%
- Physical state: clear, yellow-coloured liquid
- Composition of test material, percentage of components: 71.1% endo dicyclopentadiene, 0.8% exo dicyclopentadiene, 1.4% m-bicyclozonadiene, 15.2% CPD-MCPD codimers, 0.3% tricyclopentadiene, 1.3% CPD-butadiene codimer, 0.3% CPD-piperylene codimer, 0.3% CPD-isoprene codimer, <0.1% benzene , remainder misc. hydrocarbons.
- Specific gravity: 0.971
- Storage condition of test material: room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Interfauna (UK) Ltd., Wyton, Huntingdon, Cambridgeshire
- Age at study initiation: 5-8 weeks
- Weight at study initiation: males 120-146 g; females 120-150 g
- Fasting period before study: overnight
- Housing: In groups of up to 5, sexes separately in solid floor polypropylene cages with sawdust bedding.
- Diet: Rat and Mouse Expanded Diet No. 1 (Special Diet Services Ltd., Witham, Essex, UK) ad libitum (except for overnight fast immediately prior to dosing and approximately 2 hours after dosing)
- Water: Mains drinking water ad libitum
- Acclimation period: At least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-21
- Humidity (%): 45-68
- Air changes (per hr): approx 15
- Photoperiod (hrs dark / hrs light): 12 / 12
IN-LIFE DATES: From: 22 September 1988 To: 18 October 1988
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Maximum dose volume applied: 2.06 mL/kg
Minimum dose volume applied: 0.51 mL/kg - Doses:
- 500, 794, 1260 and 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observed 1 and 4 hours after dosing and once daily thereafter. Body weights recorded on day of dosing (day 0), days 7, 14 or at death.
- Necropsy of survivors performed: yes - Statistics:
- The acute oral LD50 and 95% confidence limits calculated using the probit method.
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 590 mg/kg bw
- 95% CL:
- 393 - 886
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 512 mg/kg bw
- 95% CL:
- 227 - 1 155
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 676 mg/kg bw
- 95% CL:
- 444 - 1 030
- Mortality:
- All deaths occurred one or two days following dosing. There were 2, 4, 5 and 5 male deaths and 1, 2, 5 and 5 females deaths in the 500, 794, 1260 and 2000 mg/kg bw groups respectively.
- Clinical signs:
- other: Hunched posture, piloerection, lethargy and decreased respiratory rate were present in all animals during the day of dosing. Ptosis was occasionally noted in animals dosed with 794 and 1260 mg/kg during this period. All rats dosed with 2000 mg/kg had ptos
- Gross pathology:
- Haemorrhagic lungs, dark liver and sloughing of the non-glandular gastric epithelium was seen in decedents. No abnormalities were seen in animals killed at the end of the study.
Applicant's summary and conclusion
- Interpretation of results:
- other: Harmful if swallowed
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral LD50 and 95% confidence limits of DCPD 75% were calculated to be 590 (393 - 886) mg/Kg bw for males and females combined; 512 (227 - 1155) mg/Kg bw for males and 676 (444 - 1030) mg/Kg bw for females.
- Executive summary:
Groups of 5 male and 5 female Sprague Dawley rats (fasted overnight) were dosed by gavage at levels of 500, 794, 1260 or 2000 mg/Kg DCPD and were observed daily for 14 days after dosing. At the 4 hour observation period rats dosed with high levels of DCPD (1260 or 2000 mg/Kg bw) had hunched posture, piloerection, lethargy and decreased respiratory rate, with ptosis and occasional signs of ataxia seen in those dosed at 2000 mg/Kg bw . All rats dosed at 1260 or 2000 mg/Kg bw died one or two days after dosing. Haemorrhagic lungs, dark liver and sloughing of the non-glandular gastric epithelium was seen in decedents.
The LD50 was calculated to be 590 mg/Kg bw (male/female), 512 mg/Kg bw for males and 676 mg/Kg bw for females.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)
Although ECHA is providing a lot of online material in your language, part of this page is only in English. More about ECHA’s multilingual practice.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
the-echa-website-uses-cookies
find-out-more-on how-we-use-cookies