Docosan-1-ol

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2009-09-30

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods with acceptable restrictions

Remarks:

Test procedure in accordance with national standard methods (ASTM) without GLP.

Qualifier:

according to guideline

Guideline:

other: ASTM E 1148

Deviations:

no

GLP compliance:

no

Type of method:

flask method

Key result

Water solubility:

< 1 mg/L

Temp.:

23 °C

pH:

5.5

Remarks on result:

other: detection limit 1 mg/L

Measurement

(triple determination)

Results:Not Detected / Not Detected / Not Detected

Mean Concentration in Water:<1.0 mg/L

Standard Deviation for These Data:none

Conclusions:

A water solubility value of <1 mg/L at 23 °C and pH 5.5 was determined for the substance using a relevant test method. The result is considered to be reliable.

Executive summary:

Docosan-1 -ol was determined according ASTM E 1148. The water solubility was under the detection limit (1 mg/L).

Description of key information

The water solubility of a commercial sample of docosan-1-ol is <1 mg/L at 23°C and pH 5.5. An estimated water solubility of ca. 0.001 mg/L (Fisk et al., 2010), using a predictive method based on log K_ow and validated based on trends across the category.

Key value for chemical safety assessment

Water solubility:

0.001 mg/L

at the temperature of:

20 °C

Additional information

A water solubility value of <1 mg/L at 23°C and pH 5.5 was determined for the substance with the use of a flask method in accordance with ASTM E 1148. The result is considered to be reliable.

It is supported by an estimated water solubility of ca. 0.001 mg/L (Fisk et al., 2010), using a predictive method based on log K_ow.

The predicted result is used in exposure modelling.

Discussion of trends in the Category of C6-24 linear and essentially-linear aliphatic alcohols:

As chain length increases, water solubility decreases, because the free energy required for a molecule to dissolve becomes less favourable for larger molecules.