Registration Dossier
Registration Dossier
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EC number: 203-584-7 | CAS number: 108-45-2
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- Staining study-not relevant
Data source
Reference
- Reference Type:
- publication
- Title:
- Yellow staining of skin among plastics workers
- Author:
- Cohen SR, and Ross PM
- Year:
- 1 988
- Bibliographic source:
- Arch. Dermatol., 124(1):19-20
Materials and methods
- Principles of method if other than guideline:
- Mice were exposed to the test substance dermally for 7 days.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- m-phenylenediamine
- EC Number:
- 203-584-7
- EC Name:
- m-phenylenediamine
- Cas Number:
- 108-45-2
- Molecular formula:
- C6H8N2
- IUPAC Name:
- m-phenylenediamine
- Details on test material:
- m-phenylenediamine, purity not reported
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Balb/c
Administration / exposure
- Details on exposure:
- Route of Administration: dermal
- Duration of treatment / exposure:
- 7 days
- Frequency of treatment:
- once per day
Doses / concentrations
- Remarks:
- Doses / Concentrations:
50 µL of a 44% (w/v) ethanol solution
- Details on study design:
- Test material was applied to the shaved-back skin of Balb/C mice, daily for seven days.
Results and discussion
Results of examinations
- Details on results:
- The test material did not stain the skin, but caused light yellow discoloration of the fur adjacent to the cutaneous application site after four days.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
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