Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
toxicity to reproduction: other studies
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Remarks:
RTECS personal communication. no details given on study design

Data source

Reference
Reference Type:
other: RTECS
Title:
No information
Author:
Sheu CW
Year:
1977
Bibliographic source:
Personal communication. FDA, Genetic Toxicology Branch (March 25) (cited in RTECS)

Materials and methods

GLP compliance:
no
Type of method:
in vivo

Test material

Constituent 1
Chemical structure
Reference substance name:
m-phenylenediamine
EC Number:
203-584-7
EC Name:
m-phenylenediamine
Cas Number:
108-45-2
Molecular formula:
C6H8N2
IUPAC Name:
m-phenylenediamine

Test animals

Species:
rat
Sex:
male

Administration / exposure

Route of administration:
intraperitoneal
Duration of treatment / exposure:
30 days

Results and discussion

Observed effects

Fetal death at 375 mg/kg

Applicant's summary and conclusion