Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
toxicity to reproduction: other studies
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Remarks:
RTECS personal communication. no details given on study design

Data source

Reference
Reference Type:
other: RTECS
Title:
No information
Author:
Sheu CW
Year:
1977
Bibliographic source:
Personal communication. FDA, Genetic Toxicology Branch (March 25) (cited in RTECS)

Materials and methods

GLP compliance:
no
Type of method:
in vivo

Test material

Constituent 1
Chemical structure
Reference substance name:
m-phenylenediamine
EC Number:
203-584-7
EC Name:
m-phenylenediamine
Cas Number:
108-45-2
Molecular formula:
C6H8N2
IUPAC Name:
m-phenylenediamine

Test animals

Species:
rat
Sex:
male

Administration / exposure

Route of administration:
intraperitoneal
Duration of treatment / exposure:
30 days

Results and discussion

Observed effects

Fetal death at 375 mg/kg

Applicant's summary and conclusion

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