Registration Dossier
Registration Dossier
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EC number: 224-221-9 | CAS number: 4253-34-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 961
- Report date:
- 1961
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Methylsilanetriyl triacetate
- EC Number:
- 224-221-9
- EC Name:
- Methylsilanetriyl triacetate
- Cas Number:
- 4253-34-3
- Molecular formula:
- C7H12O6Si
- IUPAC Name:
- methylsilanetriyl triacetate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 7 h
- Concentrations:
- Saturated atmosphere estimated to be 690.4 ppm
- No. of animals per sex per dose:
- Three
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Remarks on result:
- other: Not determined.
Any other information on results incl. tables
Animals were drowsy in 30 minutes. Bloody noses with laboured breathing observed upon removal from chamber. Some liver and kidney injury observed at autopsy. No further details.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- In an acute inhalation study (reliability score 4) 1/3 rats died following exposure to a saturated atmosphere (estimated to be 690.4 ppm) of methylsilanetriyl triacetate for 7 hours.
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