Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 224-221-9 | CAS number: 4253-34-3
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian cell study: DNA damage and/or repair
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- This is not a standard genotoxicity test system, but it provides evidence that acetic acid, sodium salt is not genotoxic in animals.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
- Principles of method if other than guideline:
- This is not a routine genotoxicity test system. Method: 3H-thymidine incorporation measured.
- GLP compliance:
- no
- Type of assay:
- other: Testicular DNA-synthesis inhibition test (DSI test)
Test material
- Reference substance name:
- Sodium acetate
- EC Number:
- 204-823-8
- EC Name:
- Sodium acetate
- Cas Number:
- 127-09-3
- IUPAC Name:
- sodium acetate
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 25-30 g
Administration / exposure
- Route of administration:
- oral: gavage
- Duration of treatment / exposure:
- A single administration.
- Frequency of treatment:
- A single administration.
Doses / concentrationsopen allclose all
- Dose / conc.:
- 200 mg/kg bw (total dose)
- Remarks:
- Basis: nominal conc.
- Dose / conc.:
- 500 mg/kg bw (total dose)
- Remarks:
- Basis: nominal conc.
- Dose / conc.:
- 1 000 mg/kg bw (total dose)
- Remarks:
- Basis: nominal conc.
- No. of animals per sex per dose:
- No data on number of animals.
- Control animals:
- yes
- Positive control(s):
- No data.
Examinations
- Tissues and cell types examined:
- 3H-thymidine incorporation in testicular cells.
Results and discussion
Test results
- Key result
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Vehicle controls validity:
- valid
- Positive controls validity:
- not specified
- Additional information on results:
- No inhibitory effect on DNA-replication was detectable.
Applicant's summary and conclusion
- Conclusions:
- No inhibitory effect on DNA-replication was detectable in animals treated with Sodium Acetate.
- Executive summary:
The Testicular DNA-synthesis inhibition test (DSI test) was performed on male mice with Sodium Acetate. This is not a standard genotoxicity test system, but it provides evidence that acetic acid, sodium salt is not genotoxic in animals. The basis of the method is to measure 3H-thymidine incorporation. Animals receive a single oral dose by gavage at concentration of 200, 500 and 1000 mg/kg bw of test substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
