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EC number: 212-554-2 | CAS number: 826-36-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: study was performed according to OECD guideline but prior to GLP requirements, but follows principles thereof. Study was selected as key study because the dose range was tested in a closer range than the supporting study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Remarks:
- GLP not implemented at that time.
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,2,6,6-tetramethyl-4-piperidone
- EC Number:
- 212-554-2
- EC Name:
- 2,2,6,6-tetramethyl-4-piperidone
- Cas Number:
- 826-36-8
- Molecular formula:
- C9H17NO
- IUPAC Name:
- 2,2,6,6-tetramethylpiperidin-4-one
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: F. Winkelmann, Borchen, Germany
- Weight at study initiation: males 115 g, females 106 g
- Housing: 1-5 animals per cage (Makrolon type III)
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 4-8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20°C +/- 1°C
- Humidity (%): 60% +/- 5%
- Air changes (per hr): 15/h
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 21.10.1985 To: 05.11.1985
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- DOSE VOLUMES APPLIED: 1.08-1.706 mg/kg
- Doses:
- 1000, 1250, 1580 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observation up to 6 hours after application and daily thereafter, weighing before application and 1, 7 and 14 days thereafter
- Necropsy of survivors performed: yes - Statistics:
- LD50 value was determined according to Litchfield and Wilcoxon (J. Pharmacol. Exp. Ther. 96, 1949, 99).
Results and discussion
- Preliminary study:
- A preliminary study for dose finding purposes was performed but not reported.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 330 mg/kg bw
- Mortality:
- Mortality was seen in all dose groups:
1000 mg/kg bw: 0/5 males, 1/5 females (within 3.5 h)
1250 mg/kg bw: 1/5 males, 4/5 females (within 24 h)
1580 mg/kg bw: 4/5 males, 3/5 females (within 120 h) - Clinical signs:
- other: Piloerection, tremors and dizziness occured approx. 30 min after application. Slight sedation, ataxia, impaired respiration, hypothermia, temporarily abdominal posture, convulsions and halfclosed or closed eyes were observed. Animals dosed with 1000 and 1
- Gross pathology:
- Post mortem hyperemia of gastric and intestinal mucosa, extended liver and spleen were observed. One animal showed a decoloured kidney and pancreas.
Some of the necropsied animals showed hyperemia of gastric and intestinal mucosa und dark spots on the kidneys.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- Under the conditions of the study an acute oral LD50 of 1330 mg/kg bw in rats was found.
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