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The aim of study was to evaluate the effects of monoethanolamine on oxaluria and oxalate deposition in the kidneys of male and female rats. Male and female rats, Wistar strain, each weighing approximately 180 g, were fed either a control diet consisting of Purina Laboratory Chow or the control diet supplemented with 2% ethanolamine over a period of 36 days. Food and water were provided ad libitum. The daily food intake was noted in the study. The 48 hour urine sample was collected every 12 days and oxalic acid content was determined. At the completion of the experimental period the animals were euthanized and the kidneys were removed. The oxalic acid content was also determined in kidneys. Homogenates or tissue slices of liver or kidney were incubated in a milieu containing a C14-labeled substrate, ethanolamine-1,2-C14. Results revealed that supplementation of the control diet with 2% ethanolamine failed to stimulate oxalate excretion with either sex. Ethanolamine also had no effect on kidney oxalate deposition. There was no metabolic variation between male and female rats in the metabolism of possible C14-labeled oxalic acid precursors. No metabolism of oxalic-1,2-C14 acid was detected in either sex.