Registration Dossier
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EC number: 233-071-3 | CAS number: 10028-18-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
ENDPOINT SUMMARY INFORMATION FROM THE 2008/2009 EU NICKEL COMPOUNDS RISK ASSESSMENT
There is considerable evidence for the in vitro genotoxicity of nickel compounds. Positive effects are generally seen in studies of chromosomal effects (chromosomal avìberrations, sister chromatoid exchanges), cell transformation tests and tests for DNA damage and repair. Whilst there are positive results for gene mutations, the positive results in at least some of these assays could possibly be due to genetic events other than point mutations.
FOR AN EXTENSIVE DISCUSSION, REFER TO THE NICKEL SULFATE DOSSIER WHICH IS BASED ON THE CONCLUSIONS EXPLAINED IN THE 2008/2009 EUROPEAN UNION EXISITING SUBSTANCE RISK ASSESSMENT OF NICKEL (EU RAR) (EEC 793/93)
Short description of key information:
There is clear evidence indicating that nickel fluoride is genotoxic in vitro, and in particular, it is clastogenic.
Moreovere, there are a number of in vivo studies in both animals and man performed mainly on Nickel sulfate. The study by Benson (2002) shows that nickel sulphate given by inhalation seems to induce inflammation and genotoxicity in lung cells at approximately the same concentrations. The results from some of the other animal studies are conflicting. Two recent micronucleus studies were negative: one study was a 2007 guidance compliant repeated dose oral study and the other study was via intraperitoneal administration. Evidence from human studies is limited.
There are no definitive studies on germ cells, and little evidence concerning hereditable effects.
Endpoint Conclusion: Adverse effect observed (positive)
Justification for classification or non-classification
The TC C&L has agreed to classify nickel sulfate, nickel chloride, nickel nitrate and nickel carbonates as Muta. Cat. 3; R68 and these classifications are included in the 30th ATP.
This classification is confirmed in 1st ATP of the CLP where nickel fluoride is listed as index 028 -029 -00 -4
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