Registration Dossier
Registration Dossier
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EC number: 224-338-5 | CAS number: 4316-73-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets generally accepted scientific principles (non-GLP)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
- Principles of method if other than guideline:
- BASF-TEST: Several groups of 5 rats per sex and dose were treated simultaneously by gavage with preparations of the test substance in suitable vehicle. Group-wise documentation of clinical signs was performed over the 7 day study period. Body weight was determined before the start of the study only, as it was needed for determination of dose.
- GLP compliance:
- no
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- Sodium sarcosinate
- EC Number:
- 224-338-5
- EC Name:
- Sodium sarcosinate
- Cas Number:
- 4316-73-8
- Molecular formula:
- C3H7NO2.Na
- IUPAC Name:
- sodium (methylamino)acetate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- DOSAGE PREPARATION
- Stock solutions prepared: 2% for the 200 mg/kg dose group, 20% for the 1600 mg/kg dose group, 30% for the 3200 and 6400 dose group
- Dose volume applied: 10 ml/kg bw for the 200 mg/kg bw dose group; 8 ml/kg bw for the 1600 mg/kg bw dose group; 10.66 ml/kg bw for the 3200 mg/kg bw dose group; 21.4 ml/kg bw for the 6400 mg/kg bw dose group. - Doses:
- 200; 1600; 3200; 6400 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 6 400 mg/kg bw
- Mortality:
- At the highest dose (6400 mg/kg bw) one male died three days after application.
- Clinical signs:
- other: 3200, 6400 mg/kg bw: directly after application irregular respiration, convulsions; reversible within 2 days 200, 1600 mg/kg bw: piloerection; reversible within one day
- Gross pathology:
- Animal which died: intestinal paralysis, dilatation of the stomach which was filled with yellow aqueous substance
Animals sacrificed:
3200, 6400 mg/kg bw: bronchitis in 6 animals
1600 mg/kg bw: slight dilatation of the stomach in two animals
200 mg/kg bw: nothing abnormal detected
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
